Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease
Journal
Molecular Genetics and Genomic Medicine
Journal Volume
8
Journal Issue
9
Date Issued
2020
Author(s)
Abstract
Background: Galectin-3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin-3 levels, and inflammatory marker levels in patients with coronary artery disease (CAD). Results: A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin-3 levels and leukocyte counts, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metalloproteinase 9 levels (all p?<.05). The LGALS3 rs2274273, rs4644, rs4652 genotypes, and haplotypes CAC, CCC, and ACT exhibited a significant association with galectin-3 levels (for genotypes, p?=?1.05?×?10?25, 3.54?×?10?25, and 2.74?×?10?7, respectively). Multivariate analysis showed LGALS3 rs2274273 and rs4644 genotypes contributing to 20.8% variation of galectin-3 levels. However, there was no association between LGALS3 genotypes and other inflammatory marker levels. Conclusions: Our data showed strong genetic determinants of galectin-3 levels in patients with CAD. The galectin-3 levels, but not LGALS3 genotypes, were associated with multiple inflammatory marker levels. Further study may be necessary to elucidate the molecular mechanism of galectin-3 in the pathogenesis of chronic inflammatory disorders. ? 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.
SDGs
Other Subjects
C reactive protein; galectin; gelatinase B; intercellular adhesion molecule 1; LGALS3 protein, human; MMP9 protein, human; plasma protein; aged; blood; coronary artery disease; female; genetics; human; leukocyte count; male; middle aged; single nucleotide polymorphism; Aged; Blood Proteins; C-Reactive Protein; Coronary Artery Disease; Female; Galectins; Humans; Intercellular Adhesion Molecule-1; Leukocyte Count; Male; Matrix Metalloproteinase 9; Middle Aged; Polymorphism, Single Nucleotide
Publisher
Wiley-Blackwell
Type
journal article