https://scholars.lib.ntu.edu.tw/handle/123456789/533930
標題: | Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease | 作者: | Liao Y.-H. Teng M.-S. JYH-MING JIMMY JUANG FU-TIEN CHIANG Er L.-K. Wu S. Ko Y.-L. |
公開日期: | 2020 | 出版社: | Wiley-Blackwell | 卷: | 8 | 期: | 9 | 來源出版物: | Molecular Genetics and Genomic Medicine | 摘要: | Background: Galectin-3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin-3 levels, and inflammatory marker levels in patients with coronary artery disease (CAD). Results: A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin-3 levels and leukocyte counts, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metalloproteinase 9 levels (all p?<.05). The LGALS3 rs2274273, rs4644, rs4652 genotypes, and haplotypes CAC, CCC, and ACT exhibited a significant association with galectin-3 levels (for genotypes, p?=?1.05?×?10?25, 3.54?×?10?25, and 2.74?×?10?7, respectively). Multivariate analysis showed LGALS3 rs2274273 and rs4644 genotypes contributing to 20.8% variation of galectin-3 levels. However, there was no association between LGALS3 genotypes and other inflammatory marker levels. Conclusions: Our data showed strong genetic determinants of galectin-3 levels in patients with CAD. The galectin-3 levels, but not LGALS3 genotypes, were associated with multiple inflammatory marker levels. Further study may be necessary to elucidate the molecular mechanism of galectin-3 in the pathogenesis of chronic inflammatory disorders. ? 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087304677&doi=10.1002%2fmgg3.1370&partnerID=40&md5=b5af9b8024cd62b967e15cf9b9ee92f7 https://scholars.lib.ntu.edu.tw/handle/123456789/533930 |
ISSN: | 2324-9269 | DOI: | 10.1002/mgg3.1370 | SDG/關鍵字: | C reactive protein; galectin; gelatinase B; intercellular adhesion molecule 1; LGALS3 protein, human; MMP9 protein, human; plasma protein; aged; blood; coronary artery disease; female; genetics; human; leukocyte count; male; middle aged; single nucleotide polymorphism; Aged; Blood Proteins; C-Reactive Protein; Coronary Artery Disease; Female; Galectins; Humans; Intercellular Adhesion Molecule-1; Leukocyte Count; Male; Matrix Metalloproteinase 9; Middle Aged; Polymorphism, Single Nucleotide |
顯示於: | 醫學系 |
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