Anti-depressive-like and cognitive impairment alleviation effects of Gastrodia elata Blume water extract is related to gut microbiome remodeling in ApoE-/- mice exposed to unpredictable chronic mild stress
Journal
Journal of ethnopharmacology
Journal Volume
302
Journal Issue
Pt B
Date Issued
2023-02-10
Author(s)
Huang, Huai-Syuan
Lin, Yu-En
Panyod, Suraphan
Chen, Rou-An
Lin, Ying-Cheng
Chai, Laura Min Xuan
Huang, Yun-Ju
Abstract
Gastrodia elata Blume (GE) is a traditional Chinese dietary therapy used to treat neurological disorders. Gastrodia elata Blume water extract (WGE) has been shown to ameliorate inflammation and improve social frustration in mice in a chronic social defeat model. However, studies on the anti-depressive-like effects and cognitive impairment alleviation related to the impact of WGE on the gut microbiome of ApoE-/- mice remain elusive.
Subjects
Cognitive impairment; Depression; Gastrodia elata Blume water extract; Gut microbiome; Unpredictable chronic mild stress model
SDGs
Type
journal article