Immunologic changes during immunotherapy in asthmatic children: Increased IL-13 and allergen-specific IgG4 antibody levels
Journal
Annals of Allergy, Asthma and Immunology
Journal Volume
80
Journal Issue
5
Pages
419-423
Date Issued
1998
Author(s)
Abstract
Background: The prevalence of allergic diseases such as asthma, allergic rhinitis, and atopic diseases has increased in recent years. Immunotherapy with allergens is a treatment documented to have an effect on regulating cytokine production and allergen-specific antibody production. Objective: The aim of this study was to further investigate immunologic changes during immunotherapy and to explore the possible more efficient approach of immunotherapy. Methods: Asthmatic children receiving house dust mite immunotherapy were followed to learn immunologic parameters such as allergen- specific antibody levels, proliferative response of peripheral blood mononuclear cells, and cytokine change during immunotherapy. Results: The data suggested (1) IgG4 anti-mite antibody increased 8 months after immunotherapy while IgE antibody level remained the same; (2) allergen- induced, in vitro production of certain cytokines such as IL-4 and IL-10 decreased after immunotherapy; (3) IL-13 (which can induce IgG4 and IgE antibody production by B cells) increased after immunotherapy. Conclusion: Although this needs more study, IL-13 might play an important role in the generation of IgG4-blocking antibody during immunotherapy.
SDGs
Other Subjects
house dust allergen; immunoglobulin G antibody; immunoglobulin G4; interleukin 13; adolescent; antibody blood level; antibody titer; article; asthma; child; clinical article; desensitization; drug efficacy; female; human; immunostimulation; immunotherapy; male; mononuclear cell; priority journal; radioallergosorbent test
Publisher
American College of Allergy, Asthma and Immunology
Type
journal article