https://scholars.lib.ntu.edu.tw/handle/123456789/568121
標題: | Immunologic changes during immunotherapy in asthmatic children: Increased IL-13 and allergen-specific IgG4 antibody levels | 作者: | Lu F.-M. Chou C.-C. BOR-LUEN CHIANG Hsieh K.-H. |
公開日期: | 1998 | 出版社: | American College of Allergy, Asthma and Immunology | 卷: | 80 | 期: | 5 | 起(迄)頁: | 419-423 | 來源出版物: | Annals of Allergy, Asthma and Immunology | 摘要: | Background: The prevalence of allergic diseases such as asthma, allergic rhinitis, and atopic diseases has increased in recent years. Immunotherapy with allergens is a treatment documented to have an effect on regulating cytokine production and allergen-specific antibody production. Objective: The aim of this study was to further investigate immunologic changes during immunotherapy and to explore the possible more efficient approach of immunotherapy. Methods: Asthmatic children receiving house dust mite immunotherapy were followed to learn immunologic parameters such as allergen- specific antibody levels, proliferative response of peripheral blood mononuclear cells, and cytokine change during immunotherapy. Results: The data suggested (1) IgG4 anti-mite antibody increased 8 months after immunotherapy while IgE antibody level remained the same; (2) allergen- induced, in vitro production of certain cytokines such as IL-4 and IL-10 decreased after immunotherapy; (3) IL-13 (which can induce IgG4 and IgE antibody production by B cells) increased after immunotherapy. Conclusion: Although this needs more study, IL-13 might play an important role in the generation of IgG4-blocking antibody during immunotherapy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031860171&doi=10.1016%2fS1081-1206%2810%2962995-X&partnerID=40&md5=6528caa47261e30e4c7d0234d4f905d8 https://scholars.lib.ntu.edu.tw/handle/123456789/568121 |
ISSN: | 1081-1206 | DOI: | 10.1016/S1081-1206(10)62995-X | SDG/關鍵字: | house dust allergen; immunoglobulin G antibody; immunoglobulin G4; interleukin 13; adolescent; antibody blood level; antibody titer; article; asthma; child; clinical article; desensitization; drug efficacy; female; human; immunostimulation; immunotherapy; male; mononuclear cell; priority journal; radioallergosorbent test |
顯示於: | 醫學系 |
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