The relation between myocardial cyclic variation of integrated backscatter and serum concentrations of procollagen propeptides in hypertensive patients
Journal
Ultrasound in Medicine and Biology
Journal Volume
30
Journal Issue
7
Pages
885-891
Date Issued
2004
Author(s)
Abstract
Cyclic variation of integrated backscatter (IBS), or CVIBS, provides a noninvasive method to measure myocardial collagen deposition and ischemia in hypertensive patients. We hypothesized that serum procollagen propeptides can offer additional values to CVIBS for evaluating cardiac changes related to fibrosis or ischemia. A total of 21 patients were enrolled in this study and were divided into three groups according to the presence of hypertension and serum carboxyterminal propeptide of type I procollagen (PICP) concentration; these were: 7 hypertensive patients with PICP ? 127 μg/L (group 1), 7 hypertensive patients with PICP < 127 μg/L (group 2), 7 normotensive subjects with PICP < 127 μg/L (group 3). In addition to PICP, serum aminoterminal propeptide of type III procollagen (PIIINP), stress 201thalium scintigraphy and CVIBS were examined. Phase-compensated amplitudes of CVIBS at mid posterior and mid anteroseptal segments were significantly lower in group 1 (p < 0.05). Patients with fixed 201thallium perfusion defects had lower phase-compensated amplitudes of CVIBS at mid anteroseptal segment and higher PIIINP concentrations (p < 0.05). In conclusions, decrease of myocardial phase-compensated amplitude accompanied with increase of serum PICP concentration may be indicative of the underlying fibrotic process of hypertensive myocardium. Decrease of this CVIBS parameter with increase of serum PIIINP implies concomitant myocardial ischemia. (E-mail: lun0630@ha.mc.ntu.edu.tw) ? 2004 World Federation for Ultrasound in Medicine & Biology.
SDGs
Other Subjects
Backscattering; Concentration (process); Diagnosis; Disease control; Health care; Patient monitoring; Ultrasonic applications; Collagen fibers; Hypertension; Serum; Musculoskeletal system; peptide; procollagen; procollagen c proteinase; procollagen type 3 aminopropeptide; thallium 201; adult; aged; article; clinical article; concentration (parameters); controlled study; female; heart muscle; heart muscle fibrosis; heart muscle ischemia; heart perfusion; heart ventricle septum; human; hypertension; male; patient; priority journal; protein blood level; scintigraphy; Biological Markers; Case-Control Studies; Collagen; Echocardiography; Female; Humans; Hypertension; Male; Middle Aged; Myocardium; Peptide Fragments; Procollagen; Prospective Studies; Thallium Radioisotopes; Thorium; Tomography, Emission-Computed, Single-Photon
Type
journal article