https://scholars.lib.ntu.edu.tw/handle/123456789/469836
標題: | The relation between myocardial cyclic variation of integrated backscatter and serum concentrations of procollagen propeptides in hypertensive patients | 作者: | Lin Y.-H. Shiau Y.-C. RUOH-FANG YEN Lin, Lung-Chun CHAU-CHUNG WU YI-LWUN HO Huang P.-J. |
公開日期: | 2004 | 卷: | 30 | 期: | 7 | 起(迄)頁: | 885-891 | 來源出版物: | Ultrasound in Medicine and Biology | 摘要: | Cyclic variation of integrated backscatter (IBS), or CVIBS, provides a noninvasive method to measure myocardial collagen deposition and ischemia in hypertensive patients. We hypothesized that serum procollagen propeptides can offer additional values to CVIBS for evaluating cardiac changes related to fibrosis or ischemia. A total of 21 patients were enrolled in this study and were divided into three groups according to the presence of hypertension and serum carboxyterminal propeptide of type I procollagen (PICP) concentration; these were: 7 hypertensive patients with PICP ? 127 μg/L (group 1), 7 hypertensive patients with PICP < 127 μg/L (group 2), 7 normotensive subjects with PICP < 127 μg/L (group 3). In addition to PICP, serum aminoterminal propeptide of type III procollagen (PIIINP), stress 201thalium scintigraphy and CVIBS were examined. Phase-compensated amplitudes of CVIBS at mid posterior and mid anteroseptal segments were significantly lower in group 1 (p < 0.05). Patients with fixed 201thallium perfusion defects had lower phase-compensated amplitudes of CVIBS at mid anteroseptal segment and higher PIIINP concentrations (p < 0.05). In conclusions, decrease of myocardial phase-compensated amplitude accompanied with increase of serum PICP concentration may be indicative of the underlying fibrotic process of hypertensive myocardium. Decrease of this CVIBS parameter with increase of serum PIIINP implies concomitant myocardial ischemia. (E-mail: lun0630@ha.mc.ntu.edu.tw) ? 2004 World Federation for Ultrasound in Medicine & Biology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-4143085078&doi=10.1016%2fj.ultrasmedbio.2004.04.007&partnerID=40&md5=76bcd47b9297aa5f7a87e7c06b5188e4 https://scholars.lib.ntu.edu.tw/handle/123456789/469836 |
ISSN: | 0301-5629 | DOI: | 10.1016/j.ultrasmedbio.2004.04.007 | SDG/關鍵字: | Backscattering; Concentration (process); Diagnosis; Disease control; Health care; Patient monitoring; Ultrasonic applications; Collagen fibers; Hypertension; Serum; Musculoskeletal system; peptide; procollagen; procollagen c proteinase; procollagen type 3 aminopropeptide; thallium 201; adult; aged; article; clinical article; concentration (parameters); controlled study; female; heart muscle; heart muscle fibrosis; heart muscle ischemia; heart perfusion; heart ventricle septum; human; hypertension; male; patient; priority journal; protein blood level; scintigraphy; Biological Markers; Case-Control Studies; Collagen; Echocardiography; Female; Humans; Hypertension; Male; Middle Aged; Myocardium; Peptide Fragments; Procollagen; Prospective Studies; Thallium Radioisotopes; Thorium; Tomography, Emission-Computed, Single-Photon |
顯示於: | 醫學教育暨生醫倫理學科所 |
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