C-C chemokine receptor 4 (CCR4)-positive regulatory T cells interact with tumor-associated macrophages to facilitate metastatic potential after radiation
Journal
European journal of cancer (Oxford, England : 1990)
Journal Volume
198
Journal Volume
35
Journal Issue
4
Start Page
212
End Page
215
Date Issued
2024-12-01
Author(s)
Lu, Li-Feng
Wang, Chung-Chieh
Abstract
Our previous study revealed that elevated C-C motif chemokine ligand 2 (CCL2) secretion by irradiated cancer cells recruited C-C motif chemokine receptor 2 (CCR2)-positive myeloid cells and polarized M2-type tumor-associated macrophages (TAMs), promoting lung metastasis in an established mouse model. This study investigated the impact of CCL2 and TAMs on adaptive immunity.
Subjects
CCR4; Radiotherapy; Regulatory T cells; Tumor microenvironment; Tumor-associated macrophage
SDGs
Type
journal article