Cd8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of Hla-Dr+ Cd38 Cd8+ cells is associated with subsequent stable Cd4+ cell levels
Journal
Journal of Infectious Diseases
Journal Volume
170
Journal Issue
4
Pages
775-781
Date Issued
1994
Author(s)
Giorgi J.V
Hirji K
Chou C.-C
Hultin L.E
Rourke S O'
Park L
Margolick J.B
Ferbas J
Phair J.P
Saah A.J
Armenian H
Farzadegan H
Graham N
Mc Arthur J
Margolick J.B
Palenicek J
Muãoz A
Hoover D
Galai N
Jacobson L.P
Park L
Piantadosi S
Su S
Phair J.P
Bauer K
Chmiel J.S
Cohen B
Variakojis D
Wesch J
Wolinsky S.M
Detels R
Visscher B.R
Chen I
Dudley J
Fahey J.L
Ferbas J
Giorgi J.V
Martinez-Maza O
Nishanian P
Taylor J
Zack J
Rinaldo C.R
Jr
Becker J.T
Gupta P
Ho M
Kingsley L
Schrager L
Kaslow R.A
Van Raden M.J
Seminara D.
Abstract
Subsets of activated CD8+ lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became seropositive for human immunodeficiency virus type 1 (HIV). Profound CD8+ cell activation was seen in all subjects at seroconversion and 6 and 12 months later. The HLA-DR+ CD38+ CD8+ cell population, which has potent direct HIV cytotoxic T cell activity, was markedly elevated at seroconversion in all subjects. In some men, these levels remained elevated throughout the first year of infection. During the next 5 years, these men had stable CD4+ cell levels, whereas the others did not. Long-term survivors (seropositive for 9 years, >800 CD4+ cells/mm3) also had elevated levels of this subset, despite few other activated CD8+ cells. Thus, selective elevation of HLA-DR+ CD38 CD8+ cells was a marker of subsequent stable HIV disease. ? 1994 by The University of Chicago.
SDGs
Other Subjects
cd38 antigen; cd4 antigen; cd8 antigen; HLA DR antigen; lymphocyte antigen; adult; article; clinical article; controlled study; cytotoxic t lymphocyte; flow cytometry; helper cell; homosexuality; human; human cell; human immunodeficiency virus 1; human immunodeficiency virus infection; lymphocyte activation; male; priority journal; seroconversion; suppressor cell; Antigens, CD; Antigens, Differentiation; Bisexuality; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Flow Cytometry; Follow-Up Studies; HIV Seronegativity; HIV Seropositivity; HLA-DR Antigens; Homosexuality, Male; Human; Lymphocyte Activation; Male; Predictive Value of Tests; Reference Values; Support, U.S. Gov't, P.H.S.; Survival Analysis; T-Lymphocyte Subsets; Time Factors
Type
journal article