https://scholars.lib.ntu.edu.tw/handle/123456789/460198
標題: | Cd8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of Hla-Dr+ Cd38 Cd8+ cells is associated with subsequent stable Cd4+ cell levels | 作者: | Giorgi J.V HONG-NERNG HO Hirji K Chou C.-C Hultin L.E Rourke S O' Park L Margolick J.B Ferbas J Phair J.P Saah A.J Armenian H Farzadegan H Graham N Mc Arthur J Margolick J.B Palenicek J Muãoz A Hoover D Galai N Jacobson L.P Park L Piantadosi S Su S Phair J.P Bauer K Chmiel J.S Cohen B Variakojis D Wesch J Wolinsky S.M Detels R Visscher B.R Chen I Dudley J Fahey J.L Ferbas J Giorgi J.V Martinez-Maza O Nishanian P Taylor J Zack J Rinaldo C.R Jr Becker J.T Gupta P Ho M Kingsley L Schrager L Kaslow R.A Van Raden M.J Seminara D. |
公開日期: | 1994 | 卷: | 170 | 期: | 4 | 起(迄)頁: | 775-781 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Subsets of activated CD8+ lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became seropositive for human immunodeficiency virus type 1 (HIV). Profound CD8+ cell activation was seen in all subjects at seroconversion and 6 and 12 months later. The HLA-DR+ CD38+ CD8+ cell population, which has potent direct HIV cytotoxic T cell activity, was markedly elevated at seroconversion in all subjects. In some men, these levels remained elevated throughout the first year of infection. During the next 5 years, these men had stable CD4+ cell levels, whereas the others did not. Long-term survivors (seropositive for 9 years, >800 CD4+ cells/mm3) also had elevated levels of this subset, despite few other activated CD8+ cells. Thus, selective elevation of HLA-DR+ CD38 CD8+ cells was a marker of subsequent stable HIV disease. ? 1994 by The University of Chicago. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/460198 | ISSN: | 0022-1899 | DOI: | 10.1093/infdis/170.4.775 | SDG/關鍵字: | cd38 antigen; cd4 antigen; cd8 antigen; HLA DR antigen; lymphocyte antigen; adult; article; clinical article; controlled study; cytotoxic t lymphocyte; flow cytometry; helper cell; homosexuality; human; human cell; human immunodeficiency virus 1; human immunodeficiency virus infection; lymphocyte activation; male; priority journal; seroconversion; suppressor cell; Antigens, CD; Antigens, Differentiation; Bisexuality; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Flow Cytometry; Follow-Up Studies; HIV Seronegativity; HIV Seropositivity; HLA-DR Antigens; Homosexuality, Male; Human; Lymphocyte Activation; Male; Predictive Value of Tests; Reference Values; Support, U.S. Gov't, P.H.S.; Survival Analysis; T-Lymphocyte Subsets; Time Factors |
顯示於: | 醫學系 |
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