Inhibition of Viral Replication Reduces Transcriptionally Active Distinct Hepatitis B Virus Integrations With Implications on Host Gene Dysregulation
Journal
Gastroenterology
Journal Volume
162
Journal Issue
4
Pages
1160
Date Issued
2022-04
Author(s)
Hsu, Yao-Chun
Suri, Vithika
Nguyen, Mindie H
Huang, Yen-Tsung
Chen, Chi-Yi
Chang, I-Wei
Tseng, Cheng-Hao
Wu, Chun-Ying
Pan, David Z
Gaggar, Anuj
Podlaha, Ondrej
Abstract
Hepatocellular carcinogenesis of hepatitis B virus (HBV) infection may arise from integration of viral DNA into the host genome. We aimed to gauge the effect of viral inhibition on transcriptionally active HBV-host integration events and explore the correlation of viral integrations with host gene dysregulation.
Subjects
Antiviral Treatment; Chronic Hepatitis B; Hepatocellular Carcinogenesis; Transcriptome Analysis; Viral Integration
Type
journal article