Publication:
Effectiveness of fecal immunochemical testing in reducing colorectal cancer mortality from the One Million Taiwanese Screening Program

cris.lastimport.scopus2025-05-07T21:54:58Z
cris.virtual.departmentInternal Medicine
cris.virtual.departmentInternal Medicine-NTUH
cris.virtual.departmentInternal Medicine-NTUH
cris.virtual.departmentInternal Medicine-NTUH
cris.virtual.departmentInstitute of Health Data Analytics and Statistics
cris.virtual.departmentPublic Health
cris.virtual.departmentPhysical Medicine and Rehabilitation
cris.virtual.departmentPhysical Medicine and Rehabilitation-NTUH
cris.virtual.orcid0000-0002-1940-6428en_US
cris.virtual.orcid0000-0002-8160-1216en_US
cris.virtual.orcid0000-0003-2786-8056en_US
cris.virtual.orcid0000-0002-5799-6705en_US
cris.virtual.orcid0000-0001-6451-4666en_US
cris.virtualsource.department245f5ece-4692-4d90-bfcf-2100572a15b4
cris.virtualsource.department245f5ece-4692-4d90-bfcf-2100572a15b4
cris.virtualsource.department3b32742e-947d-47bf-8d23-2071d8b5b19a
cris.virtualsource.departmentffa25303-1ae3-4e7b-96e4-86f3ff993643
cris.virtualsource.department4ec79829-d15f-404d-a933-0f02059839d0
cris.virtualsource.department4ec79829-d15f-404d-a933-0f02059839d0
cris.virtualsource.department3e7537e5-73c2-4655-858b-e739af0651fc
cris.virtualsource.department3e7537e5-73c2-4655-858b-e739af0651fc
cris.virtualsource.orcid245f5ece-4692-4d90-bfcf-2100572a15b4
cris.virtualsource.orcid3b32742e-947d-47bf-8d23-2071d8b5b19a
cris.virtualsource.orcidffa25303-1ae3-4e7b-96e4-86f3ff993643
cris.virtualsource.orcid4ec79829-d15f-404d-a933-0f02059839d0
cris.virtualsource.orcid3e7537e5-73c2-4655-858b-e739af0651fc
dc.contributor.authorHAN-MO CHIUen_US
dc.contributor.authorChen S.L.-S.en_US
dc.contributor.authorYen A.M.-F.en_US
dc.contributor.authorChiu S.Y.-H.en_US
dc.contributor.authorFann J.C.-Y.en_US
dc.contributor.authorYI-CHIA LEEen_US
dc.contributor.authorSHIN-LIANG PANen_US
dc.contributor.authorMING-SHIANG WUen_US
dc.contributor.authorLiao C.-S.en_US
dc.contributor.authorChen, Tony Hsiu Hsien_US
dc.contributor.authorKoong S.-L.en_US
dc.contributor.authorChiou S.-T.en_US
dc.creatorChiu H.-M.;Chen S.L.-S.;Yen A.M.-F.;Chiu S.Y.-H.;Fann J.C.-Y.;Lee Y.-C.;Shin-Liang Pan;Wu M.-S.;Liao C.-S.;Chen H.-H.;Koong S.-L.;Chiou S.-T.
dc.date.accessioned2020-04-07T07:00:56Z
dc.date.available2020-04-07T07:00:56Z
dc.date.issued2015
dc.description.abstractBACKGROUND: The effectiveness of fecal immunochemical testing (FIT) in reducing colorectal cancer (CRC) mortality has not yet been fully assessed in a large, population-based service screening program. METHODS: A prospective cohort study of the follow-up of approximately 5 million Taiwanese from 2004 to 2009 was conducted to compare CRC mortality for an exposed (screened) group and an unexposed (unscreened) group in a population-based CRC screening service targeting community residents of Taiwan who were 50 to 69 years old. Given clinical capacity, this nationwide screening program was first rolled out in 2004. In all, 1,160,895 eligible subjects who were 50 to 69 years old (ie, 21.4% of the 5,417,699 subjects of the underlying population) participated in the biennial nationwide screening program by 2009. RESULTS: The actual effectiveness in reducing CRC mortality attributed to the FIT screening was 62% (relative rate for the screened group vs the unscreened group, 0.38; 95% confidence interval, 0.35-0.42) with a maximum follow-up of 6 years. The 21.4% coverage of the population receiving FIT led to a significant 10% reduction in CRC mortality (relative rate, 0.90; 95% confidence interval, 0.84-0.95) after adjustments for a self-selection bias. CONCLUSIONS: This large, prospective Taiwanese cohort undergoing population-based FIT screening for CRC had the statistical power to demonstrate a significant CRC mortality reduction, although the follow-up time was short. Although such findings are informative for health decision makers, continued follow-up of this large cohort will be required to estimate the long-term impact of FIT screening if the covered population is expanded. ? 2015 American Cancer Society.
dc.identifier.doi10.1002/cncr.29462
dc.identifier.issn0008-543X
dc.identifier.pmid25995082
dc.identifier.scopus2-s2.0-84940961410
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84940961410&doi=10.1002%2fcncr.29462&partnerID=40&md5=611e4d165af6783f6a7182c51d8101dd
dc.identifier.urihttps://scholars.lib.ntu.edu.tw/handle/123456789/482872
dc.publisherJohn Wiley and Sons Inc.
dc.relation.ispartofCancer
dc.relation.journalissue18
dc.relation.journalvolume121
dc.relation.pages3221-3229
dc.subject.classification[SDGs]SDG3
dc.subject.otherhemoglobin; adult; aged; Article; barium enema; cancer diagnosis; cancer incidence; cancer mortality; cancer patient; cancer registry; cancer screening; cancer staging; cause of death; clinical effectiveness; cohort analysis; colonoscopy; colorectal adenoma; colorectal cancer; controlled study; feces analysis; female; government; histopathology; human; immunohistochemistry; major clinical study; male; occult blood test; priority journal; prospective study; public health service; sigmoidoscopy; Taiwanese; tumor invasion; very elderly; Colorectal Neoplasms; early diagnosis; epidemiology; immunohistochemistry; mass screening; middle aged; mortality; occult blood; procedures; Taiwan; Aged; Cohort Studies; Colorectal Neoplasms; Early Detection of Cancer; Female; Humans; Immunohistochemistry; Male; Mass Screening; Middle Aged; Occult Blood; Prospective Studies; Taiwan
dc.titleEffectiveness of fecal immunochemical testing in reducing colorectal cancer mortality from the One Million Taiwanese Screening Programen_US
dc.typejournal articleen
dspace.entity.typePublication

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