Immunogenicity, safety, cross-reaction, and immune persistence of an inactivated enterovirus A71 vaccine in children aged from two months to 11 years in Taiwan
Journal
Vaccine
Journal Volume
37
Journal Issue
13
Pages
1827-1835
Date Issued
2019
Author(s)
Abstract
Background: To fight against enterovirus A71 (EV-A71)-associated diseases, vaccine development was initiated in Taiwan focusing on two-month-old infants. Methods: We conducted a phase II, double-blind, randomised, placebo-controlled study on infants and children aged two months to 11 years. This study was conducted in 4 parts (2a, 2b, 2c, and 2d) with age de-escalation sequentially. Two doses were administered with a 28-day or 56-day interval. Participants aged two months to
Subjects
Cross-reaction; EV-A71 vaccine; Immune persistence; Immunogenicity; Two-month-old infant
SDGs
Other Subjects
enterovirus A71 vaccine; neutralizing antibody; placebo; unclassified drug; virus vaccine; inactivated vaccine; neutralizing antibody; vaccine; virus antibody; virus vaccine; antibody titer; arthralgia; Article; child; controlled study; cross reaction; diarrhea; double blind procedure; drug dose escalation; drug megadose; drug safety; drug tolerability; ecchymosis; Enterovirus A71; fatigue; fever; headache; human; immunogenicity; infant; loss of appetite; low drug dose; myalgia; nausea and vomiting; pain; phase 2 clinical trial; preschool child; priority journal; randomized controlled trial; seroconversion; shivering; side effect; single drug dose; swelling; Taiwan; age; clinical trial; Enterovirus A; Enterovirus infection; female; immunization; immunology; male; outcome assessment; vaccination; vaccine immunogenicity; Age Factors; Antibodies, Neutralizing; Antibodies, Viral; Child; Child, Preschool; Cross Reactions; Enterovirus A, Human; Enterovirus Infections; Female; Humans; Immunization Schedule; Immunogenicity, Vaccine; Infant; Male; Patient Outcome Assessment; Taiwan; Vaccination; Vaccine Potency; Vaccines, Inactivated; Viral Vaccines
Publisher
Elsevier Ltd
Type
journal article