https://scholars.lib.ntu.edu.tw/handle/123456789/566377
標題: | Immunogenicity, safety, cross-reaction, and immune persistence of an inactivated enterovirus A71 vaccine in children aged from two months to 11 years in Taiwan | 作者: | LI-MIN HUANG Chiu C.-H. Chiu N.-C. Lin C.-Y. Li M.-T. Kuo T.-Y. Weng Y.-J. Hsieh E.-F. Tai I.-C. |
關鍵字: | Cross-reaction; EV-A71 vaccine; Immune persistence; Immunogenicity; Two-month-old infant | 公開日期: | 2019 | 出版社: | Elsevier Ltd | 卷: | 37 | 期: | 13 | 起(迄)頁: | 1827-1835 | 來源出版物: | Vaccine | 摘要: | Background: To fight against enterovirus A71 (EV-A71)-associated diseases, vaccine development was initiated in Taiwan focusing on two-month-old infants. Methods: We conducted a phase II, double-blind, randomised, placebo-controlled study on infants and children aged two months to 11 years. This study was conducted in 4 parts (2a, 2b, 2c, and 2d) with age de-escalation sequentially. Two doses were administered with a 28-day or 56-day interval. Participants aged two months to |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061823857&doi=10.1016%2fj.vaccine.2019.02.023&partnerID=40&md5=d04466a1fad13a888a1fdb0d8152abd0 https://scholars.lib.ntu.edu.tw/handle/123456789/566377 |
ISSN: | 0264-410X | DOI: | 10.1016/j.vaccine.2019.02.023 | SDG/關鍵字: | enterovirus A71 vaccine; neutralizing antibody; placebo; unclassified drug; virus vaccine; inactivated vaccine; neutralizing antibody; vaccine; virus antibody; virus vaccine; antibody titer; arthralgia; Article; child; controlled study; cross reaction; diarrhea; double blind procedure; drug dose escalation; drug megadose; drug safety; drug tolerability; ecchymosis; Enterovirus A71; fatigue; fever; headache; human; immunogenicity; infant; loss of appetite; low drug dose; myalgia; nausea and vomiting; pain; phase 2 clinical trial; preschool child; priority journal; randomized controlled trial; seroconversion; shivering; side effect; single drug dose; swelling; Taiwan; age; clinical trial; Enterovirus A; Enterovirus infection; female; immunization; immunology; male; outcome assessment; vaccination; vaccine immunogenicity; Age Factors; Antibodies, Neutralizing; Antibodies, Viral; Child; Child, Preschool; Cross Reactions; Enterovirus A, Human; Enterovirus Infections; Female; Humans; Immunization Schedule; Immunogenicity, Vaccine; Infant; Male; Patient Outcome Assessment; Taiwan; Vaccination; Vaccine Potency; Vaccines, Inactivated; Viral Vaccines |
顯示於: | 醫學系 |
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