Recurrence of corneal neovascularization associated with lipid deposition after subconjunctival injection of bevacizumab
Journal
Cornea
Journal Volume
32
Journal Issue
11
Pages
1446-1453
Date Issued
2013
Author(s)
Abstract
Purpose: To report 7 cases of recurrent corneal neovascularization (NV) and lipid deposition after subconjunctival injection of bevacizumab for the treatment of corneal NV-induced lipid keratopathy. Methods: We conducted a prospective interventional case series that included 20 eyes of chronic lipid keratopathy that received bevacizumab injection for the treatment of corneal NV and lipid deposition, including 7 eyes with recurrent corneal NV and lipid deposition after ceasing treatment. Repeated subconjunctival injections of bevacizumab were performed in 5 patients with recurrence. Penetrating keratoplasty was performed in 1 patient who had severely recurrent lipid deposition. Clinical presentation of corneal NV and lipid deposition, best-corrected visual acuity, and complications after treatments were recorded. Results: Bevacizumab inhibited corneal NV and lipid depositions in 19 patients. Seven of the 20 patients (35%) had different patterns of recurrence of corneal NV/lipid deposition 6 to 15 months after discontinuing treatment. Five of the 7 patients in whom corneal NV/lipid deposition was recurrent received another course of repeated bevacizumab treatments. Three eyes had partial response to the second course of treatment. Two eyes had too short re-treatment course to have conclusions. One patient who received penetrating keratoplasty had successful result after surgery. Conclusions: Corneal NV and lipid deposition may recur after ceasing the subconjunctival bevacizumab injections for lipid keratopathy. Some patients respond at least partially to repeated injections. ? 2013 Lippincott Williams & Wilkins.
SDGs
Other Subjects
bevacizumab; adult; aged; article; cataract; cataract extraction; child; clinical article; cornea neovascularization; cornea ulcer; disease association; drug tolerability; endophthalmitis; female; follow up; glaucoma; herpes simplex keratitis; human; intervention study; keratopathy; lipidosis; male; penetrating keratoplasty; priority journal; prospective study; recurrent disease; retreatment; school child; skin defect; treatment response; uveitis; visual acuity; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Corneal Neovascularization; Female; Humans; Injections, Intraocular; Lipid Metabolism Disorders; Male; Middle Aged; Prospective Studies; Recurrence; Treatment Failure
Type
journal article