https://scholars.lib.ntu.edu.tw/handle/123456789/517808
標題: | Recurrence of corneal neovascularization associated with lipid deposition after subconjunctival injection of bevacizumab | 作者: | HSIAO-SANG CHU TA-CHING CHEN FUNG-RONG HU WEI-LI CHEN |
公開日期: | 2013 | 卷: | 32 | 期: | 11 | 起(迄)頁: | 1446-1453 | 來源出版物: | Cornea | 摘要: | Purpose: To report 7 cases of recurrent corneal neovascularization (NV) and lipid deposition after subconjunctival injection of bevacizumab for the treatment of corneal NV-induced lipid keratopathy. Methods: We conducted a prospective interventional case series that included 20 eyes of chronic lipid keratopathy that received bevacizumab injection for the treatment of corneal NV and lipid deposition, including 7 eyes with recurrent corneal NV and lipid deposition after ceasing treatment. Repeated subconjunctival injections of bevacizumab were performed in 5 patients with recurrence. Penetrating keratoplasty was performed in 1 patient who had severely recurrent lipid deposition. Clinical presentation of corneal NV and lipid deposition, best-corrected visual acuity, and complications after treatments were recorded. Results: Bevacizumab inhibited corneal NV and lipid depositions in 19 patients. Seven of the 20 patients (35%) had different patterns of recurrence of corneal NV/lipid deposition 6 to 15 months after discontinuing treatment. Five of the 7 patients in whom corneal NV/lipid deposition was recurrent received another course of repeated bevacizumab treatments. Three eyes had partial response to the second course of treatment. Two eyes had too short re-treatment course to have conclusions. One patient who received penetrating keratoplasty had successful result after surgery. Conclusions: Corneal NV and lipid deposition may recur after ceasing the subconjunctival bevacizumab injections for lipid keratopathy. Some patients respond at least partially to repeated injections. ? 2013 Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886086433&doi=10.1097%2fICO.0b013e31825ec407&partnerID=40&md5=597066fb277408a06f8551602ca5ec03 https://scholars.lib.ntu.edu.tw/handle/123456789/517808 |
ISSN: | 0277-3740 | DOI: | 10.1097/ICO.0b013e31825ec407 | SDG/關鍵字: | bevacizumab; adult; aged; article; cataract; cataract extraction; child; clinical article; cornea neovascularization; cornea ulcer; disease association; drug tolerability; endophthalmitis; female; follow up; glaucoma; herpes simplex keratitis; human; intervention study; keratopathy; lipidosis; male; penetrating keratoplasty; priority journal; prospective study; recurrent disease; retreatment; school child; skin defect; treatment response; uveitis; visual acuity; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Corneal Neovascularization; Female; Humans; Injections, Intraocular; Lipid Metabolism Disorders; Male; Middle Aged; Prospective Studies; Recurrence; Treatment Failure |
顯示於: | 醫學系 |
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