Unibody core-shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging
Journal
Biomaterials
Journal Volume
37
Pages
436-446
Date Issued
2015
Author(s)
Abstract
Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core-shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. By conjugating Gd3+ at the stable core and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we developed a theranostic NPs (UCS-Gd-Dox) that achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1=0.9 and 14.5mm-1s-1 at pH 7.4 and 5.5, respectively). The anti-cancer effect of UCS-Gd-Dox is significantly better than free Dox in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. To the best of our knowledge, this is the simplest approach to obtain the theranostic NPs with Gd-conjugation and Dox doping. ? 2014 Elsevier Ltd.
Subjects
Core-shell; Drug delivery; Magnetic resonance imaging (MRI); Nanoparticle
SDGs
Other Subjects
Controlled drug delivery; Drug delivery; Magnetic resonance imaging; Nanomagnetics; Nanoparticles; Polymers; Shells (structures); Core shell; Drug release; Enhanced Permeability and Retention effect; Magnetic Resonance Imaging (MRI); Multi-functional nanoparticles; pH sensitive; Smart polymers; Triggered release; Targeted drug delivery; doxorubicin; gadolinium; polymer; unclassified drug; unibody core shell polymer; nanoparticle; polymer; animal experiment; antineoplastic activity; Article; controlled study; drug delivery system; drug penetration; drug release; encapsulation; female; human; human cell; mouse; nonhuman; nuclear magnetic resonance imaging; pH; priority journal; 3T3 cell line; animal; diagnostic use; HeLa cell line; nonobese diabetic mouse; SCID mouse; time; ultrastructure; Animals; Drug Delivery Systems; Female; Gadolinium; HeLa Cells; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Mice; Mice, Inbred NOD; Mice, SCID; Nanoparticles; NIH 3T3 Cells; Polymers; Time Factors
Type
journal article