Paget's disease of the bone: A case report
Journal
Journal of the Formosan Medical Association
Journal Volume
100
Journal Issue
2
Pages
137-141
Date Issued
2001
Author(s)
Abstract
Paget's disease of bone is rare in Asia. We report a case of Paget's disease in a 58-year-old Taiwanese man who was admitted with a 3-month history of bilateral numbness in the buttock region. Laboratory data disclosed an elevated serum alkaline phosphatase level (510 U/L). Plain radiographs of the lumber spine showed generalized increased density at the third lumbar vertebra, associated with cortical thickening, loss of cortico-cancellous definition, and increased anteroposterior diameter. The T1-weighted magnetic resonance image of the lumbar spine showed diffuse, heterogenous low signal intensity at the third lumbar vertebral body, pedicle, laminae, and spinal process; these areas showed mixed high and low signal intensity on the T2-weighted image. Technetium-99m bone scan revealed abnormal uptake in the involved vertebra. Histologic examination of the third lumbar spinal process confirmed the diagnosis of Paget's disease of bone. The patient remained well during a follow-up period of 6 months.
Subjects
Paget's disease Taiwan
SDGs
Other Subjects
alkaline phosphatase; gadolinium pentetate; technetium 99m; adult; alkaline phosphatase blood level; article; biopsy; bone density; bone scintiscanning; buttock; case report; contrast enhancement; cortical bone; histopathology; human; lumbar spine; male; nuclear magnetic resonance imaging; osteoblast; osteoclast; Paget bone disease; paresthesia; spine radiography; Taiwan; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Osteitis Deformans
Type
journal article