Impact of PNPLA3 p.I148M and Hepatic Steatosis on Long-Term Outcomes for Hepatocellular Carcinoma and HBsAg Seroclearance in Chronic Hepatitis B
Journal
Journal of Hepatocellular Carcinoma
Journal Volume
9
Pages
301
Date Issued
2022
Author(s)
Hsueh, Rei-Chi
Wu, Wan-Jung
Lin, Chih-Lin
Huang, Yi-Wen
Hu, Jui-Ting
Wu, Chih-Feng
Sung, Feng-Yu
Liu, Wen-Jie
Abstract
Coexistence of hepatitis B and nonalcoholic fatty liver disease is common; however, little is known about the impact of hepatic steatosis and its major genetic determinants on the natural history of HBV infection. We aimed to study the effects of hepatic steatosis and PNPLA3 variant p.I148M on the risk of hepatocellular carcinoma (HCC) and the lifetime probability of HBsAg seroclearance, which is associated with functional remission and improved long-term outcome of HBV infection.
Subjects
HBsAg seroclearance; PNPLA3; chronic hepatitis B; hepatic steatosis; hepatocellular carcinoma; liver cirrhosis
SDGs
Publisher
DOVE MEDICAL PRESS LTD
Type
journal article