https://scholars.lib.ntu.edu.tw/handle/123456789/629482
標題: | Impact of PNPLA3 p.I148M and Hepatic Steatosis on Long-Term Outcomes for Hepatocellular Carcinoma and HBsAg Seroclearance in Chronic Hepatitis B | 作者: | Hsueh, Rei-Chi Wu, Wan-Jung Lin, Chih-Lin CHUN-JEN LIU Huang, Yi-Wen Hu, Jui-Ting Wu, Chih-Feng Sung, Feng-Yu Liu, Wen-Jie MING-WHEI YU |
關鍵字: | HBsAg seroclearance; PNPLA3; chronic hepatitis B; hepatic steatosis; hepatocellular carcinoma; liver cirrhosis | 公開日期: | 2022 | 出版社: | DOVE MEDICAL PRESS LTD | 卷: | 9 | 起(迄)頁: | 301 | 來源出版物: | Journal of Hepatocellular Carcinoma | 摘要: | Coexistence of hepatitis B and nonalcoholic fatty liver disease is common; however, little is known about the impact of hepatic steatosis and its major genetic determinants on the natural history of HBV infection. We aimed to study the effects of hepatic steatosis and PNPLA3 variant p.I148M on the risk of hepatocellular carcinoma (HCC) and the lifetime probability of HBsAg seroclearance, which is associated with functional remission and improved long-term outcome of HBV infection. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629482 | ISSN: | 2253-5969 | DOI: | 10.2147/JHC.S355540 |
顯示於: | 流行病學與預防醫學研究所 |
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