Histones of Neutrophil Extracellular Traps Directly Disrupt the Permeability and Integrity of the Intestinal Epithelial Barrier
Journal
Inflammatory bowel diseases
Journal Volume
29
Journal Issue
5
Pages
783–797
Date Issued
2023-05-02
Author(s)
Abstract
Increased neutrophil extracellular trap (NET) formation and abundant NET-associated proteins are frequently found in the inflamed colon of patients with inflammatory bowel disease. Peptidyl arginine deiminase 4 (PAD4) activation is essential for the generation of NET and NET-mediated pathogenesis. However, the role of PAD4-dependent NET formation in murine inflammatory bowel disease models and the molecular mechanisms responsible for the altered gut barrier function are unknown.
Subjects
adherens junctions; histones; intestinal barrier permeability; intestinal epithelial cells; neutrophil extracellular traps; peptidyl arginine deiminase 4; tight junctions
Publisher
OXFORD UNIV PRESS INC
Type
journal article