https://scholars.lib.ntu.edu.tw/handle/123456789/631758
標題: | Histones of Neutrophil Extracellular Traps Directly Disrupt the Permeability and Integrity of the Intestinal Epithelial Barrier | 作者: | Lai, Hsuan-Ju Doan, Ha T Lin, Elliot Y Chiu, Yi-Ling Cheng, Yuan-Kai Lin, Yi-He Hao-Sen Chiang |
關鍵字: | adherens junctions; histones; intestinal barrier permeability; intestinal epithelial cells; neutrophil extracellular traps; peptidyl arginine deiminase 4; tight junctions | 公開日期: | 2-五月-2023 | 出版社: | OXFORD UNIV PRESS INC | 卷: | 29 | 期: | 5 | 起(迄)頁: | 783–797 | 來源出版物: | Inflammatory bowel diseases | 摘要: | Increased neutrophil extracellular trap (NET) formation and abundant NET-associated proteins are frequently found in the inflamed colon of patients with inflammatory bowel disease. Peptidyl arginine deiminase 4 (PAD4) activation is essential for the generation of NET and NET-mediated pathogenesis. However, the role of PAD4-dependent NET formation in murine inflammatory bowel disease models and the molecular mechanisms responsible for the altered gut barrier function are unknown. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/631758 | ISSN: | 1078-0998 | DOI: | 10.1093/ibd/izac256 |
顯示於: | 生命科學系 |
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