https://scholars.lib.ntu.edu.tw/handle/123456789/144618
標題: | Arsenic Cancer Risk Posed to Human Health from Tilapia Consumption in Taiwan | 作者: | Liao C.-M. Shen H.-H. Lin T.-L. Chen S.-C. CHI-LING CHEN Hsu L.-I. CHUNG-MIN LIAO LIAO, CHUNG- MIN |
關鍵字: | arsenic;human health;epidemiology;bioaccumulation;tilapia;cancer;risk;blackfoot disease | 公開日期: | 2008 | 起(迄)頁: | 27-37 | 來源出版物: | Ecotoxicology and Environmental Safety | 摘要: | Ingested inorganic arsenic is strongly associated with a wide spectrum of adverse health outcomes. We propose a bioaccumulation and the Weibull model-based epidemiological framework to accurately estimate the reference arsenic intake guideline for tilapia consumption and tilapia- cultured water arsenic concentration based on bioaccumulations of tilapia and gender/age/cancer-specific epidemiological data from the arseniasis- endemic area in Taiwan. Our results show a positive relationship between arsenic exposure and age/gender- and cancer-specific cumulative incidence ratio using Weibull dose-response model . Based on male bladder cancer with an excess lifetime cancer risk of 10(-4), we estimate the reference tilapia inorganic arsenic guideline value to be 0.084 mu g g(-1) dry wt based on the suggested daily consumption rate of 120 g d (-1). Our findings show that consumption of tilapia in a blackfoot disease (BFD)- endemic area poses no significant cancer risk (excess cancer risks ranging from 3.4 x 10(-5) to 9.3 x 10(-5)), implying that people in BFD-endemic areas are not readily associated with higher fatalities for bladder cancer exposed from tilapia consumption. We are confident that our model can be easily adapted for other aquaculture species, and encourage risk managers to use the model to evaluate the potential population-level long-term low- dose cancer risks. We conclude that, by integrating the bioaccumulation concept and epidemiological investigation of humans exposed to arsenic, we can provide a scientific basis for risk analysis to enhance risk management strategies. (C) 2007 Elsevier Inc. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/175420 | DOI: | 10.1016/j.ecoenv.2007.10.018 | SDG/關鍵字: | arsenic; aquaculture; arsenic; bioaccumulation; cancer; cichlid; dose-response relationship; estimation method; food consumption; health risk; modeling; pollution exposure; aquaculture; article; bioaccumulation; blackfoot disease; bladder cancer; cancer risk; endemic disease; health hazard; human; liver cancer; lung cancer; nonhuman; risk assessment; risk management; Taiwan; Tilapia; Animals; Arsenic; Carcinogens; Female; Food Contamination; Humans; Male; Models, Biological; Neoplasms; Risk Assessment; Taiwan; Tilapia; Water Pollutants, Chemical; Water Supply; Asia; Eurasia; Far East; Taiwan; Tilapia |
顯示於: | 臨床醫學研究所 |
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