DC 欄位 | 值 | 語言 |
dc.contributor | 臺大醫院;臺大醫院-小兒部;臺大醫院-檢驗醫學部;臺大醫學院-臨床醫學研究所;臺大醫學院-醫學檢驗暨生物技術學系暨研究所; | en |
dc.contributor.author | Yang, Yung-Li | en |
dc.creator | Yang, Yung-Li;Hsiao, Chih-Cheng;Chen, Hsuan-Yu;Lin, Kai-Hsin;Jou, Shiann-Tarng;Chen, Jiann-Shiuh;Chang, Te-Kau;Sheen, Jiunn-Ming;Yu, Sung-Liang;Lu, Meng-Yao;Cheng, Chao-Neng;Wu, Kang-Hsi;Wang, Shih-Chung;Wang, Jiaan-Der;Chang, Hsiu-Hao;Lin, Shu-Rung;Lin, Shu-Wha;Lin, Dong-Tsamn | en |
dc.creator | 林東燦 ;俞松良 ;周獻堂 ;林淑華 ;盧孟佑 ;張修豪 ;林凱信 ;楊永立 | zh-tw |
dc.date | 2012 | en |
dc.date.accessioned | 2014-02-14T08:23:54Z | - |
dc.date.accessioned | 2018-07-06T08:33:35Z | - |
dc.date.available | 2014-02-14T08:23:54Z | - |
dc.date.available | 2018-07-06T08:33:35Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/259585 | - |
dc.description.abstract | Background The absence of biallelic TCR? deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T-cell acute lymphoblastic leukemia (ALL). This study aimed to investigate its prognostic value in Taiwanese patients with T-cell ALL. Procedure. Forty-five children with T-cell ALL were enrolled from six medical centers in Taiwan. Quantitative DNA polymerase chain reaction (Q-PCR) was performed to check the status of TCR gamma deletion. The threshold for homozygous deletions by Q-PCR was defined as a fold-change <0.35. Results. ABD was found in 20 patients [20:45] who had higher incidences of induction failure than those without ABD (P = 0.03; hazard ratio [HR] = 8.13; 95% confidence interval [95% CI] 1.23-53.77) after multivariate regression analysis. Patents with ABD also had inferior EFS and OS (P = 0.071 and 0.0196, respectively). Multivariate Cox analysis indicated that the association between ABD and overall survival was independent of age and leukocyte count on presentation (P = 0.036; HR = 4.25; 95% CI = 1.10-16.42). Conclusions. The absence of TCRg deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T-cell ALL in Taiwan. Providing patients with T-cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials. Pediatr Blood Cancer 2012;58:846-851. (C) 2011 Wiley Periodicals, Inc. | en |
dc.format.extent | 99 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en-us | en |
dc.relation | Pediatr. Blood Cancer, 58(6), 846-851 | en |
dc.relation.ispartof | Pediatr. Blood Cancer | - |
dc.subject | absence of TCR? deletion | en |
dc.subject | childhood T-cell ALL | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Absence of biallelic TCR? deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia | en |
dc.relation.pages | 846-851 | - |
dc.relation.journalvolume | 58 | - |
dc.relation.journalissue | 6 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/259585/1/index.html | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
顯示於: | 醫學檢驗暨生物技術學系
|