https://scholars.lib.ntu.edu.tw/handle/123456789/146779
Title: | Absence of biallelic TCR? deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia | Authors: | Yang, Yung-Li | Keywords: | absence of TCR? deletion;childhood T-cell ALL | Issue Date: | 2012 | Journal Volume: | 58 | Journal Issue: | 6 | Start page/Pages: | 846-851 | Source: | Pediatr. Blood Cancer | Abstract: | Background The absence of biallelic TCR? deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T-cell acute lymphoblastic leukemia (ALL). This study aimed to investigate its prognostic value in Taiwanese patients with T-cell ALL. Procedure. Forty-five children with T-cell ALL were enrolled from six medical centers in Taiwan. Quantitative DNA polymerase chain reaction (Q-PCR) was performed to check the status of TCR gamma deletion. The threshold for homozygous deletions by Q-PCR was defined as a fold-change <0.35. Results. ABD was found in 20 patients [20:45] who had higher incidences of induction failure than those without ABD (P = 0.03; hazard ratio [HR] = 8.13; 95% confidence interval [95% CI] 1.23-53.77) after multivariate regression analysis. Patents with ABD also had inferior EFS and OS (P = 0.071 and 0.0196, respectively). Multivariate Cox analysis indicated that the association between ABD and overall survival was independent of age and leukocyte count on presentation (P = 0.036; HR = 4.25; 95% CI = 1.10-16.42). Conclusions. The absence of TCRg deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T-cell ALL in Taiwan. Providing patients with T-cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials. Pediatr Blood Cancer 2012;58:846-851. (C) 2011 Wiley Periodicals, Inc. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/259585 |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
File | Description | Size | Format | |
---|---|---|---|---|
index.html | 23.15 kB | HTML | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.