https://scholars.lib.ntu.edu.tw/handle/123456789/160548
Title: | Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas | Authors: | Chen, Hui-Chun Chu, Ricky-Y. Hsu, Ping-Ning |
Keywords: | Gastric cancer;E-cadherin;Differentiation;Invasion;Prognosis | Issue Date: | 2003 | Start page/Pages: | 97-106 | Source: | Cancer Letters 201 | Abstract: | Perturbation in E-cadherin expression leads to loss of cellular adhesion with possible consequence of cellular transformation and tumor progression. The aims of this study were to determine E-cadherin expression in each subtype of gastric cancer classified by different classification systems, and to investigate the role of E-cadherin in cell differentiation, cancer invasion and metastasis. Expression of E-cadherin was analyzed in 84 patients with gastric adenocarcinoma by immunohistochemistry and correlated with clinicopahotlogical parameters. Our results showed loss of E-cadherin expression in 0% (0/3), 20.0% (9/45), 48% (15/31), 100% (3/3) and 100% (2/2) of papillary, tubular, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma by Japanese histological classification. The reduction of E-cadherin expression was inversely correlated with the grade of differentiation. According to the histological classification of Lauren and Ming, the frequency of lost E-cadherin expression was higher in diffuse type (65%) and infiltrative type (64%) gastric cancer than in intestinal type (20%, P ,0:001 Þ and expanding type cancer (22%, P ,0:001 Þ ; respectively. The loss of E-cadherin expression was significantly associated with tumor invasion ð P ,0:05 Þ : Furthermore, there was a borderline association between the loss of E-cadherin expression and poor survival ð P ¼ 0:109 Þ : These data demonstrated a striking correlation between E-cadherin expression and the differentiation of gastric carcinoma. The loss of E-cadherin expression may contribute to gastric cancer invasion to adjacent organs. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/2006111501222542 | Other Identifiers: | 246246/2006111501222542 |
Appears in Collections: | 免疫學研究所 |
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