https://scholars.lib.ntu.edu.tw/handle/123456789/188297
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 內科 | en |
dc.contributor.author | Tseng, Ching-Ping | en |
dc.contributor.author | Huang, Chien-Ling | en |
dc.contributor.author | Huang, Ching-Hui | en |
dc.contributor.author | Cheng, Ju-Chien | en |
dc.contributor.author | Stern, Arnold | en |
dc.contributor.author | Tseng, Chin-Hsiao | en |
dc.creator | 曾慶孝 | zh-tw |
dc.creator | Tseng, Ching-Ping; Huang, Chien-Ling; Huang, Ching-Hui; Cheng, Ju-Chien; Stern, Arnold; Tseng, Chin-Hsiao; Chiu, Daniel Tsun-Yee | en |
dc.date | 2003 | en |
dc.date.accessioned | 2008-12-29T07:20:07Z | - |
dc.date.accessioned | 2018-07-11T05:29:49Z | - |
dc.date.available | 2008-12-29T07:20:07Z | - |
dc.date.available | 2018-07-11T05:29:49Z | - |
dc.date.issued | 2003 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/95246 | - |
dc.description.abstract | Previous studies have shown that Disabled-2 (DAB2) is up- regulated during megakaryocytic differentiation of human K 562 cells. To delineate the consequences of DAB2 induction, a DNA vector-based small interfering RNA (siRNA) was designed to intervene in DAB2 expression. We found that DAB2 siRNA specifically inhibited DAB2 induction, resulting in the modulation of cell-cell adhesion and mitogen-activated protein kinase ( MAPK) phosphorylation. The morphological changes and 03 integrin expression associated with megakaryocytic differentiation were not affected. Since the MAPK pathway has been shown to involve DAB2 induction [Tseng et al., Biochem. Biophys. Res. Commun. 285 (2001) 129-135], our results suggest a reciprocal regulation between DAB2 and MAPK in the differentiation of K562 cells. In addition, we have demonstrated for the first time that DAB2 siRNA is a valuable tool for unveiling the biological consequences of DAB2 expression. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | FEBS LETTERS v.541 n.1-3 pp.21-27 | en |
dc.relation.ispartof | FEBS LETTERS | - |
dc.subject | disabled-2 | en |
dc.subject | small interfering RNA | en |
dc.subject | K562 cell | en |
dc.subject | megakaryocytic differentiation | en |
dc.subject | mitogen-activated protein kinase | en |
dc.title | Disabled-2 Small Interfering Rna Modulates Cellular Adhesive Function and Mapk Activity during Megakaryocytic Differentiation of K562 Cells | en |
dc.type | journal article | en |
dc.relation.pages | 21-27 | - |
dc.relation.journalvolume | v.541 | - |
dc.relation.journalissue | n.1-3 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
顯示於: | 醫學系 |
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