https://scholars.lib.ntu.edu.tw/handle/123456789/188415
標題: | 國人血脂異常相關之基因研究─金山居民之血脂異常的基因遺傳(II) | 其他標題: | Genetic heritability of dyslipoproteinemia in Chin-Shan Inhabitants(II) | 作者: | 李源德 | 關鍵字: | 家族聚集;血脂肪值;家族相關係數 | 公開日期: | 1998 | 出版社: | 臺北市:國立臺灣大學醫學院內科 | 摘要: | 本計畫是第一個有關本土高脂血家族 相關因子的研究,先就金山社區研究全部世代的3602 鄉民中找出血脂異常患者作 為指標個案(proband ),以此家族現存資 料搜尋配偶組,親子組,兄弟姐妹組,及 祖孫組,延伸現有資料人群到他們的兒女 親戚,研究其血中脂肪值的家族聚集情 形。結果共有三家族的研究對象113 人(男51 人,女62 人),平均年齡35.6 歲,顯示 以高脂血作為指標個案所找到的三個家族 成員其年齡雖然年輕很多,但其高脂血的 分佈情形確實比原世代的分佈來得高。以 家族內血脂肪濃度作相關研究得知:配偶 的相關係數在LDL 值為負相關,在ApoA1 值為正相關,親子代之間的相關係數在 HDL 及ApoB 為正相關,兄弟姐妹手足之 間的各種血脂肪值相關係數上並無明顯的 相關性,祖孫之間的相關值在各種血脂肪 值均呈明顯負相關的關係。表示在隔代的 血脂肪分佈有明顯相反的變化,此結果顯 示環境及飲食習慣的影響在血脂肪濃度有 很強的影響,本研究將進一步分析是否可能有單一基因或多重基因相關。 This project is to study the familial aggregation of blood lipid level in Chin-Shan community. We enrolled three families, involved 113 persons, with extended pedigree. The relationships among family were confirmed by formal documents. The study groups were much younger than original cohort population, but with higher triglyceride levels and similar levels of cholesterol and Apo B levels. The familial correlation coefficient were calculated by the FCOR program implemented in SAGE software. We found that among marital relationships, there were positive ApoA1 correlation(r=0.73), and negative ApoB correlation (r=0.23). Among the parental-offspring relationships, there was a moderate positive correlation in HDL-C level(r=0.34); and apparently no correlation between siblings yet. Among the pairs of grandparents and grandchildren, significant negative correlations were identified for total cholesterol, triglyceride and ApoB. Different patterns of correlations among the parents and offsprings were identified such as. There were strong positive relationships between fathers and daughters in the levels of triglyceride and apoB levels. In conclusion, this study dermonstrated an familial aggregation on lipid levels, environmental influences on does play an important role in part of our study the lipid levels within family members, especially between grandparents and grandchildren. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/29759 | 其他識別: | 872314B002238M40 | Rights: | 國立臺灣大學醫學院內科 |
顯示於: | 醫學系 |
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872314B002238M40.pdf | 31.25 kB | Adobe PDF | 檢視/開啟 |
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