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  4. 心室輔助器在心衰竭動物模型利用微流體通道上離子運動特性的研究及其相關之應用
 
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心室輔助器在心衰竭動物模型利用微流體通道上離子運動特性的研究及其相關之應用

Date Issued
2005-07-31
Date
2005-07-31
Author(s)
周迺寬
DOI
932314B002234
URI
http://ntur.lib.ntu.edu.tw//handle/246246/24547
Abstract
As the use of ventricular assist device (VAD) has increased dramatically during the past decade, it is necessary to understand the hemodynamic change and interaction between VAD and physiological ionic signal transmission. The improvement for Taita No.1 VAD was still persist no matter the preparation of polyurethane, endothelial cell culture prevent thrombosis, newer streamline of impeller design, the biocontroller development that matches physiological requirement, and spectrum analysis of flow and pressure. All things have to make additional efforts. Because physiological signal changes will happen when patients are under VAD-treatment, ion movement versus expressions of neural signal transmissions becomes extremely important. By selecting a point of view in engineering to discuss physical mechanisms occurred in ion movement that is much helpful in clinical diagnosis and the following therapeutic development. We introduce the basic knowledge of a neuron in the following sections to illustrate that why we are interest in physical mechanisms in ion movements and we also try to solve the problem according to some models as far as we know. Though the signal transmitted of neuron of different types has sizable differences, the form of signals are basically the same, all consist of change of the electric potential on the cell membrane of neuron. The electric potential perturbation produced by a part of cells will be spread to the surrounding area gradually, and then finished the information 3 transmission. Unless the signal amplification caused of energy supplement acquired by neuron, with the increase with the distance among the signal sources and neuron, the perturbation will gradually weaken.
Subjects
Ventricle assist device
Ion
channel
Publisher
臺北市:國立臺灣大學醫學院外科
Type
report
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932314B002234.pdf

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