https://scholars.lib.ntu.edu.tw/handle/123456789/194450
Title: | β1型轉化生長因子於腎肥大過程中肝細胞生長因子失調之角色 | Authors: | 曹永魁 | Keywords: | 肝細胞生長因子;β1 型轉化生長因子;腎切除後代償性腎肥大;hepatocyte growth factor;transforming growth factor β1;postnephrectomy compensatory renal growth | Issue Date: | 2003 | Publisher: | 臺北市:國立臺灣大學醫學院小兒科 | Abstract: | 我們將25 天大之大白鼠右腎切除研究其左腎於術後6 小時、12 小時、24 小時、48 小時、72 小時及7 天之腎臟生長及肝細胞生長因子(HGF),β1 型轉化 生長因子(TGF-β1)、C-met 蛋白及TGF-β1 mRNA之變化情形。結果發現腎中HGF/ TGF-β1 比值於術後12 小時實驗組有意義高於控制組,而TGF-β1 mRNA 則於 12-24 小時達到最低,C-met 蛋白則在6~24 小時明顯增加,而顯著的腎肥大(腎 臟重量增加)則發生在術後7 天之實驗組。 Kidney growth and growth factors change were observed after unilateral nephrectomy in the 25-day-old rats. Renal HGF/TGF-β1 ratio was found significantly higher at 12 hours after nephrectomy. C-met receptor protein was remarkably increased at the first 24 hours associated with low renal TGF-β1 and TGF-β1 mRNA at least at the 12~24 hours after nephrectomy. Kidney weight was increased at 7 days after nephrectomy, but not in the first 72 hours. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/22887 | Other Identifiers: | 912314B002214 | Rights: | 國立臺灣大學醫學院小兒科 |
Appears in Collections: | 醫學系 |
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912314B002214.pdf | 69.75 kB | Adobe PDF | View/Open |
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