https://scholars.lib.ntu.edu.tw/handle/123456789/202035
Title: | Osteopontin基因在急性呼吸窘迫症候群, 結核性肋膜炎及肺外結核病人之表現 Expression of osteopontin gene in patients with tuberculous pleurisy and miliary tuberculosis |
Authors: | ���R�R | Keywords: | osteopontin;結核菌;肋膜炎;粟粒性;肉芽腫;Mycobacterium tuberculosis;pleurisy;miliary;granuloma | Issue Date: | 31-Jul-2005 | Publisher: | 臺北市:國立臺灣大學醫學院檢驗醫學科 | Abstract: | osteopontin 是由巨噬細胞與T 淋巴球產生的介 質(matrix) 蛋白. 過去已有報告顯示, 在結核病 造成的肉芽腫(granuloma), osteopontin 之表 現很強. 亦有報告顯示, 肺結核病人血液中的 osteopontin 濃度比正常人血液中的值高出很多. 本計畫旨在研究結核性肋膜炎及粟粒性結核病人 血液中osteopontin 的濃度, 並與正常人血液中的 值比較, osteopontin 的濃度測定是使用ELISA 法. 研究結果顯示, 結核性肋膜炎及粟粒性結核病人血 漿中的osteopontin 比正常人血漿中的值, 有顯 著之上升. Osteopontin, a noncollagenous matrix protein produced by macrophages and T lymphocytes, is expressed in granulomatous lesions caused byMycobacterium tuberculosis infection. Circulating osteopontin levels have been found to be elevated in patients with pulmonary tuberculosis, and correlate with severity of pulmonary tuberculosis. In the present study we investigated plasma osteopontin levels in patients with tuberculous pleurisy, those with miliary tuberculosis, as there was no reports of such study, and compared them with those of normal control subjects. We found that plasma osteopontin levels, as measured by an ELISA assay, were significantly higher in patients with tuberculous pleurisy, those with miliary tuberculosis, than in healthy control subjects. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/27350 | Other Identifiers: | 932314B002221 | Rights: | 國立臺灣大學醫學院檢驗醫學科 |
Appears in Collections: | 醫學系 |
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932314B002221.pdf | 147.13 kB | Adobe PDF | View/Open |
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