Cytotoxic dolabellane diterpenes from the Formosan soft coral Clavularia inflata
Journal
Journal of Natural Products
Journal Volume
64
Journal Issue
8
Pages
1028-1031
Date Issued
2001
Author(s)
Abstract
Six new cytotoxic dolabellane diterpenes, (1R*,12R*)-dolabella-4(16),7,10-triene-3,13-dione (1), (1R*,7R*,8S*,-12R*)-dolabella-4(16),10-diene-7,8- epoxy- 3,13-dione (2), (1R*,10R*,11S*,12R*)-dolabella-4(16),7-diene-10, 11-epoxy-3,13-dione (3), (1R*)-dolabella-4(16),7,11(12)-triene-3,13-dione (4), (1R*,3R*)-3-hydroxydolabella-4(16),7,11(12)-triene-3,13-dione (5), and (1R*,7R*)-7-hydroperoxydolabella-4(16),8(17),11(12)-triene-3, 13-dione (6), have been isolated from the Formosan soft coral Clavularia inflata. The structures of compounds 1-6 were determined by 1D and 2D spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
SDGs
Other Subjects
3 hydroxydolabella 4(16),7,11(12) triene 3,13 dione; 7 hydroperoxydolabella 4(16),8(17),11(12) triene 3,13 dione; antineoplastic agent; cytotoxic agent; diterpene; dolabella 4(16),10 diene 7,8 epoxy 3,13 dione; dolabella 4(16),7 diene 10,11 epoxy 3,13 dione; dolabella 4(16),7,10 triene 3,13 dione; dolabella 4(16),7,11(12) triene 3,13 dione; unclassified drug; article; carbon nuclear magnetic resonance; coral; cytotoxicity; drug isolation; drug structure; human; human cell; proton nuclear magnetic resonance; spectroscopy; structure analysis; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cnidaria; Diterpenes; Humans; Leukemia P388; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stereoisomerism; Taiwan; Tumor Cells, Cultured; Alcyonacea; Anthozoa; Clavularia; Dolabella; Invertebrata
Type
journal article