https://scholars.lib.ntu.edu.tw/handle/123456789/356013
標題: | Escape of herpesviruses from the nucleus | 作者: | Lee, Chung-Pei MEI-RU CHEN |
公開日期: | 2010 | 卷: | 20 | 期: | 4 | 起(迄)頁: | 214-230 | 來源出版物: | Reviews in Medical Virology | 摘要: | The nuclear envelope of eukaryotic cells is composed of double lipid-bilayer membranes, the membrane-connected nuclear pore complexes and an underlying nuclear lamina network. The nuclear pore complexes serve as gates for regulating the transport of macromolecules between cytoplasm and nucleus. The nuclear lamina not only provides an intact mesh work for maintaining the nuclear stiffness but also presents a natural barrier against most DNA viruses. Herpesviruses are large DNA viruses associated with multiple human and animal diseases. The complex herpesviral virion contains more than 30 viral proteins. After viral DNA replication, the newly synthesised genome is packaged into the pre-assembled intranuclear capsid. The nucleocapsid must then transverse through the nuclear envelope to the cytoplasm for the subsequent maturation process. Information regarding how nucleocapsid breaches the rigid nuclear lamina barrier and accesses the inner nuclear membrane for primary envelopment has emerged recently. From the point of view of both viral components and nuclear structure, this review summarises recent advances in the complicated protein-protein interactions and the phosphorylation regulations involved in the nuclear egress of herpesviral nucleocapsids. Copyright ? 2010 John Wiley & Sons, Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-77953302554&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/356013 |
DOI: | 10.1002/rmv.643 | SDG/關鍵字: | membrane protein; phosphotransferase; nucleocapsid protein; Alphaherpesvirinae; cell nucleus; cell nucleus membrane; cytoplasm; DNA replication; DNA virus; Gammaherpesvirinae; Herpes virus; macromolecule; nonhuman; nuclear lamina; nuclear pore; protein interaction; protein phosphorylation; regulatory mechanism; review; virion; virus genome; virus nucleocapsid; active transport; animal; cell nucleus; genetics; herpes virus infection; human; metabolism; protein transport; virology; Active Transport, Cell Nucleus; Animals; Cell Nucleus; Cytoplasm; Herpesviridae; Herpesviridae Infections; Humans; Nucleocapsid Proteins; Protein Transport |
顯示於: | 醫學系 |
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