DC 欄位 | 值 | 語言 |
dc.contributor | 臺大公衛學院-流行病學與預防醫學研究所; | en |
dc.contributor.author | Hwang, Bing-Fang | en |
dc.contributor.author | YUNG-LING LEE | en |
dc.contributor.author | Young, Li-Hao | en |
dc.contributor.author | Tsai, Ching-Hui | en |
dc.contributor.author | Tung, Kuan-Yen | en |
dc.contributor.author | Wang, Pei-Chuan | en |
dc.contributor.author | Su, Ming-Wei | en |
dc.contributor.author | Lee, Yungling Leo | en |
dc.contributor.author | West, James | en |
dc.creator | Hwang, Bing-Fang; Young, Li-Hao; Tsai, Ching-Hui; Tung, Kuan-Yen; Wang, Pei-Chuan; Su, Ming-Wei; Lee, Yungling Leo; West, James | - |
dc.date.accessioned | 2018-09-10T09:51:52Z | - |
dc.date.available | 2018-09-10T09:51:52Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84872868223&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/382254 | - |
dc.description.abstract | Background: There are limited studies on the role of interaction between exposure to ambient air pollution and glutathione-S-transferase (GST) P1 on the risk of asthma/wheezing among children, which provided suggestive, but inconclusive results. Methods: To assess the joint effect of air pollutants and GSTP1 on asthma/wheezing, we conducted a nationwide cross-sectional study of 3,825 children in Taiwan Children Health Study. The studied determinants were three GSTP1 Ile105Val (rs 1695) genotypes (Ile-Ile; Ile-Val and Val-Val) and expoure to ambient air pollutants. We used routine air-pollution monitoring data for ozone (O3) and particles with an aerodynamic diameter of 2.5 μm or less (PM2.5). The effect estimates were presented as odds ratios (ORs) per interquartile changes for PM2.5 and O3. Findings: In a two-stage hierarchical model adjusting for confounding, the risk of asthma was negatively associated with PM2.5 (adjusted odds ratio (OR) 0.60; 95% confidence interval (CI) 0.45, 0.82) and O3 (OR 0.74; 95% CI 0.60, 0.90) among Ile105 homozygotes, but positively associated with PM2.5 (OR 1.52; 95% CI 1.01, 2.27) and O3 (OR 1.19; 95% CI 0.91, 1.57) among those with at least one val105 allele (interaction p value = 0.001 and 0.03, respectively). A similar tendency of effect modification between PM2.5 and O3 and GSTP1 on wheezing was found. Conclusion: Children who carried Ile105 variant allele and exposed to PM2.5 and O3 may be less likely to occurrence of asthma/wheezing. ? 2013 Hwang et al. | - |
dc.format.extent | 110 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en | en |
dc.relation | PLoS One, 8(1) | en |
dc.relation.ispartof | PLoS ONE | en_US |
dc.source | AH-Scopus to ORCID | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | carbon monoxide; glutathione transferase M1; glutathione transferase P1; glutathione transferase T1; nitric oxide; ozone; sulfur dioxide; adolescent; air pollutant; air pollution; allele; ambient air; article; asthma; atopy; child; controlled study; cross-sectional study; disease association; DNA polymorphism; environmental exposure; female; genetic variability; genotype environment interaction; homozygote; human; major clinical study; male; maternal smoking; ozone layer; particle size; pollution monitoring; risk factor; school child; sex difference; Taiwan; validity; wheezing; Adolescent; Air Pollutants; Asthma; Child; Environmental Exposure; Female; Glutathione S-Transferase pi; Humans; Male; Ozone; Particle Size; Polymorphism, Genetic | - |
dc.title | Fine Particle, Ozone Exposure, and Asthma/Wheezing: Effect Modification by Glutathione S-transferase P1 Polymorphisms | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1371/journal.pone.0052715 | - |
dc.relation.journalvolume | 8 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.orcid | 0000-0002-2234-9479 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
顯示於: | 流行病學與預防醫學研究所
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