https://scholars.lib.ntu.edu.tw/handle/123456789/382254
Title: | Fine Particle, Ozone Exposure, and Asthma/Wheezing: Effect Modification by Glutathione S-transferase P1 Polymorphisms | Authors: | Hwang, Bing-Fang YUNG-LING LEE Young, Li-Hao Tsai, Ching-Hui Tung, Kuan-Yen Wang, Pei-Chuan Su, Ming-Wei Lee, Yungling Leo West, James |
Issue Date: | 2013 | Journal Volume: | 8 | Journal Issue: | 1 | Source: | PLoS ONE | Abstract: | Background: There are limited studies on the role of interaction between exposure to ambient air pollution and glutathione-S-transferase (GST) P1 on the risk of asthma/wheezing among children, which provided suggestive, but inconclusive results. Methods: To assess the joint effect of air pollutants and GSTP1 on asthma/wheezing, we conducted a nationwide cross-sectional study of 3,825 children in Taiwan Children Health Study. The studied determinants were three GSTP1 Ile105Val (rs 1695) genotypes (Ile-Ile; Ile-Val and Val-Val) and expoure to ambient air pollutants. We used routine air-pollution monitoring data for ozone (O3) and particles with an aerodynamic diameter of 2.5 μm or less (PM2.5). The effect estimates were presented as odds ratios (ORs) per interquartile changes for PM2.5 and O3. Findings: In a two-stage hierarchical model adjusting for confounding, the risk of asthma was negatively associated with PM2.5 (adjusted odds ratio (OR) 0.60; 95% confidence interval (CI) 0.45, 0.82) and O3 (OR 0.74; 95% CI 0.60, 0.90) among Ile105 homozygotes, but positively associated with PM2.5 (OR 1.52; 95% CI 1.01, 2.27) and O3 (OR 1.19; 95% CI 0.91, 1.57) among those with at least one val105 allele (interaction p value = 0.001 and 0.03, respectively). A similar tendency of effect modification between PM2.5 and O3 and GSTP1 on wheezing was found. Conclusion: Children who carried Ile105 variant allele and exposed to PM2.5 and O3 may be less likely to occurrence of asthma/wheezing. ? 2013 Hwang et al. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84872868223&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/382254 |
DOI: | 10.1371/journal.pone.0052715 | SDG/Keyword: | carbon monoxide; glutathione transferase M1; glutathione transferase P1; glutathione transferase T1; nitric oxide; ozone; sulfur dioxide; adolescent; air pollutant; air pollution; allele; ambient air; article; asthma; atopy; child; controlled study; cross-sectional study; disease association; DNA polymorphism; environmental exposure; female; genetic variability; genotype environment interaction; homozygote; human; major clinical study; male; maternal smoking; ozone layer; particle size; pollution monitoring; risk factor; school child; sex difference; Taiwan; validity; wheezing; Adolescent; Air Pollutants; Asthma; Child; Environmental Exposure; Female; Glutathione S-Transferase pi; Humans; Male; Ozone; Particle Size; Polymorphism, Genetic |
Appears in Collections: | 流行病學與預防醫學研究所 |
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