A simple formula useful for positional cloning
Journal
Genetics
Journal Volume
160
Pages
353-355
Date Issued
2002
Author(s)
Richard T. Durrett
Kai-Yi Chen
Steven D. Tanksley
Abstract
We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and hence should be useful for planning positional cloning experiments. The predictions of this formula agree well with the results from a number of published experiments in Arabidopsis.
Type
journal article