A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA
Journal
Chemical Communications
Journal Volume
55
Journal Issue
11
Pages
1548-1551
Date Issued
2019
Author(s)
Abstract
A dual signal amplification method based on surface-enhanced Raman scattering (SERS) is developed by photo-triggered release of SERS probes from mesoporous silica-coated Au nanorods (SiO2@Au) and the use of a specially-designed SERS substrate with an internal reference. Two metal carbonyl (metal-CO) labels (Os-SCO and Re-SCO) are proposed here as novel interference-free labels. Results demonstrate that tumor-related DNA can be quantitatively detected by this reliable and ultra-sensitive SERS platform. ? 2019 The Royal Society of Chemistry.
SDGs
Other Subjects
carbonyl derivative; circulating tumor DNA; gold nanorod; mesoporous silica nanoparticle; coordination compound; DNA; gold; nanotube; osmium; rhenium; silicon dioxide; Article; branched DNA signal amplification assay; cancer diagnosis; controlled study; nasopharynx cancer; quantitative analysis; standard; surface enhanced Raman spectroscopy; chemistry; genetics; human; laser; metabolism; neoplasm; pathology; Raman spectrometry; Coordination Complexes; DNA, Neoplasm; Gold; Humans; Lasers; Nanotubes; Neoplasms; Osmium; Rhenium; Silicon Dioxide; Spectrum Analysis, Raman
Type
journal article