https://scholars.lib.ntu.edu.tw/handle/123456789/406750
標題: | Effects of glutathione on amyloid fibrillation of hen egg-white lysozyme | 作者: | Wang S.S.-S. Chou S.-W. Liu K.-N. Wu C.-H. |
關鍵字: | Amyloid fibril;Lysozyme;Redox composition | 公開日期: | 2009 | 卷: | 45 | 期: | 4 | 起(迄)頁: | 321-329 | 來源出版物: | International Journal of Biological Macromolecules | 摘要: | This study examined the effects of glutathione on the fibrillation of hen egg-white lysozyme. We found that the fibrillation of lysozyme was considerably reduced by GSH while no anti-aggregating activity was detected with only GSSG. SDS-PAGE results also revealed that the addition of GSH led to an early occurrence of prominent lysozyme hydrolysis. Moreover, GSH was effective in inhibiting lysozyme fibrillation when GSH was added within 6 days of incubation. We conclude that the attenuation of lysozyme fibrillation is strongly dependent upon the redox environment. Our data may contribute to decipher the molecular mechanism of amyloid fibrillation. ? 2009 Elsevier B.V. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/406750 | ISSN: | 01418130 | DOI: | 10.1016/j.ijbiomac.2009.08.003 |
顯示於: | 化學工程學系 |
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