https://scholars.lib.ntu.edu.tw/handle/123456789/408824
標題: | Gelatin-functionalized mesoporous silica nanoparticles with sustained release properties for intracameral pharmacotherapy of glaucoma | 作者: | Liao Y.-T. Lee C.-H. Chen S.-T. Lai J.-Y. Wu K.C.-W. |
公開日期: | 2017 | 卷: | 5 | 期: | 34 | 起(迄)頁: | 7008-7013 | 來源出版物: | Journal of Materials Chemistry B | 摘要: | Herein, pilocarpine-loaded gelatin-covered mesoporous silica nanoparticles (denoted as p/GM) were intracamerally administrated into the anterior chamber for the reduction of intraocular pressure (IOP). The in vitro release profile shows that p/GM demostrates a high release percentage (50%) with a long-lasting release profile (36 days). The in vivo studies showed the maintenance of IOP in eye with ocular hypertension for 21 days. ? 2017 The Royal Society of Chemistry. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/408824 | ISSN: | 20507518 | DOI: | 10.1039/c7tb01217a |
顯示於: | 化學工程學系 |
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