https://scholars.lib.ntu.edu.tw/handle/123456789/408836
標題: | Multimodal Superparamagnetic Nanoparticles with Unusually Enhanced Specific Absorption Rate for Synergetic Cancer Therapeutics and Magnetic Resonance Imaging | 作者: | Thorat N.D. Bohara R.A. Malgras V. Tofail S.A.M. Ahamad T. Alshehri S.M. Wu K.C.-W. Yamauchi Y. |
關鍵字: | drug delivery systems;magnetic fluid hyperthermia;magnetic resonance imaging;polyethylene glycol;superparamagnetic nanoparticles | 公開日期: | 2016 | 卷: | 8 | 期: | 23 | 起(迄)頁: | 14656-14664 | 來源出版物: | ACS Applied Materials and Interfaces | 摘要: | Superparamagnetic nanoparticles (SPMNPs) used for magnetic resonance imaging (MRI) and magnetic fluid hyperthermia (MFH) cancer therapy frequently face trade off between a high magnetization saturation and their good colloidal stability, high specific absorption rate (SAR), and most importantly biological compatibility. This necessitates the development of new nanomaterials, as MFH and MRI are considered to be one of the most promising combined noninvasive treatments. In the present study, we investigated polyethylene glycol (PEG) functionalized La1-xSrxMnO3 (LSMO) SPMNPs for efficient cancer hyperthermia therapy and MRI application. The superparamagnetic nanomaterial revealed excellent colloidal stability and biocompatibility. A high SAR of 390 W/g was observed due to higher colloidal stability leading to an increased Brownian and Neel's spin relaxation. Cell viability of PEG capped nanoparticles is up to 80% on different cell lines tested rigorously using different methods. PEG coating provided excellent hemocompatibility to human red blood cells as PEG functionalized SPMNPs reduced hemolysis efficiently compared to its uncoated counterpart. Magnetic fluid hyperthermia of SPMNPs resulted in cancer cell death up to 80%. Additionally, improved MRI characteristics were also observed for the PEG capped La1-xSrxMnO3 formulation in aqueous medium compared to the bare LSMO. Taken together, PEG capped SPMNPs can be useful for diagnosis, efficient magnetic fluid hyperthermia, and multimodal cancer treatment as the amphiphilicity of PEG can easily be utilized to encapsulate hydrophobic drugs. ? 2016 American Chemical Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/408836 | ISSN: | 19448244 | DOI: | 10.1021/acsami.6b02616 | SDG/關鍵字: | Biocompatibility; Blood; Cell culture; Cell death; Cells; Cytology; Diseases; Economic and social effects; Hyperthermia therapy; Magnetic fluids; Magnetic resonance imaging; Magnetism; Manganese oxide; Nanoparticles; Nanostructured materials; Noninvasive medical procedures; Polyethylene glycols; Polyethylenes; Radar imaging; Resonance; Saturation magnetization; Superparamagnetism; Biological compatibility; Colloidal Stability; Drug delivery system; Human red blood cell; Magnetic fluid hyperthermia; Non-invasive treatment; Specific absorption rate; Superparamagnetic nanoparticles; Nanomagnetics; macrogol; magnetite nanoparticle; chemistry; devices; human; neoplasm; nuclear magnetic resonance imaging; Humans; Magnetic Resonance Imaging; Magnetite Nanoparticles; Neoplasms; Polyethylene Glycols |
顯示於: | 化學工程學系 |
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