Modeling the physiological glucose-insulin system on normal and diabetic subjects
Journal
Computer Methods and Programs in Biomedicine
Journal Volume
97
Journal Issue
2
Pages
130-140
Date Issued
2010
Author(s)
Tsai H.-W.
Abstract
This paper aims to present a mathematical model to describe the plasma glucose and insulin daily variations on normal and diabetic subjects. The proposed model consists of two delay differential equations (DDEs) where five adjustable parameters are used to characterize the respective dynamics and oscillation behavior of normal and diabetic subjects. Several clinical data tests demonstrate that the suggested model is practical to approach the daily-life glucose dynamics on normal, diabetic Type 1 and Type 2 subjects. Moreover, the corresponding parameters are fairly persuasive to identify the patients' conditions of physiological functions. ? 2009 Elsevier Ireland Ltd. All rights reserved.
Subjects
Delay differential equations (DDEs)
Glucose-insulin system
Human endocrinology
Parametric estimation
Physiology
SDGs
Other Subjects
Adjustable parameters; Clinical data; Delay differential equations; Delay differential equations (DDEs); Human endocrinology; Oscillation behavior; Parametric estimation; Physiological functions; Physiological glucose; Plasma glucose; Two delays; Differential equations; Endocrinology; Estimation; Glucose; Insulin; Mathematical models; Physiological models; glucose; insulin; article; blood glucose monitoring; daily life activity; diabetes mellitus; diagnostic accuracy; endocrine function; endocrine system examination; glucose blood level; glucose insulin system; human; insulin blood level; insulin dependent diabetes mellitus; insulin release; mathematical model; molecular dynamics; non insulin dependent diabetes mellitus; oscillation; pathophysiology; Computer Simulation; Diabetes Mellitus; Dietary Carbohydrates; Glucose; Humans; Hyperglycemia; Insulin; Metabolic Clearance Rate; Models, Biological; Pancreas
Type
journal article