Recrystallization of acetaminophen and sulindac from the batch and continuous supercritical anti-solvent precipitation

Abstract

Recrystallization and micronization of pharmaceuticals of acetaminophen and sulindac using supercritical anti-solvent (SAS) methods were investigated in this study. Carbon dioxide was used as the anti-solvent, and ethanol or acetone was used as the solvent. Crystalline particles were obtained from the original amorphous and irregular morphologies. Taking the acetaminophen for example, the particle size was originally up to 200 £gm. It reduced to 10 to 50 £gm after the batch SAS treatment, and to leb than 10 £gm in the continuous SAS proceb.