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  4. Methylene-blue-encapsulated liposomes as photodynamic therapy nano agents for breast cancer cells
 
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Methylene-blue-encapsulated liposomes as photodynamic therapy nano agents for breast cancer cells

Journal
Nanomaterials
Journal Volume
9
Journal Issue
1
Date Issued
2019
Author(s)
Wu P.-T.
Lin C.-L.
Lin C.-W.
Chang N.-C.
Tsai W.-B.
Tsai W.-B.  
DOI
10.3390/nano9010014
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/410327
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059405383&doi=10.3390%2fnano9010014&partnerID=40&md5=f63e26d4281b41acc9eed6758626c5a5
Abstract
Methylene blue (MB) is a widely used dye and photodynamic therapy (PDT) agent that can produce reactive oxygen species (ROS) after light exposure, triggering apoptosis. However, it is hard for the dye to penetrate through the cell membrane, leading to poor cellular uptake; thus, drug carriers, which could enhance the cellular uptake, are a suitable solution. In addition, the defective vessels resulting from fast vessel outgrowth leads to an enhanced permeability and retention (EPR) effect, which gives nanoscale drug carriers a promising potential. In this study, we applied poly(12-(methacryloyloxy)dodecyl phosphorylcholine), a zwitterionic polymer-lipid, to self-assemble into liposomes and encapsulate MB (MB-liposome). Its properties of high stability and fast intracellular uptake were confirmed, and the higher in vitro ROS generation ability of MB-liposomes than that of free MB was also verified. For in vivo tests, we examined the toxicity in mice via tail vein injection. With the features found, MB-liposome has the potential of being an effective PDT nano agent for cancer therapy. ? 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Subjects
Breast cancer cell
Liposome
Methylene blue
Photodynamic therapy
Zwitterion
SDGs

[SDGs]SDG3

Type
journal article

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To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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