Trifunctional Fe 3 O 4 /CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy
Journal
ACS Biomaterials Science and Engineering
Journal Volume
3
Journal Issue
10
Pages
2366-2374
Date Issued
2017
Author(s)
Abstract
Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe 3 O 4 ) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe 3 O 4 /CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe 3 O 4 /CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe 3 O 4 /CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems. ? 2017 American Chemical Society.
Subjects
bladder cancer
controlled release
core-shell-corona nanoparticles
magnetic guidance
targeting
SDGs
Other Subjects
Biocompatibility; Chemotherapy; Diseases; Iron research; Magnetism; Nanoparticles; Nanostructures; Particle size; Shells (structures); Synthesis (chemical); Bladder cancer cells; Bladder cancers; Controlled release; Core shell; Drug delivery system; Surface functionalities; Targeted chemotherapy; targeting; Nanomagnetics; alginic acid; arginylglycylaspartic acid; calcium phosphate; doxorubicin; superparamagnetic iron oxide nanoparticle; Article; biocompatibility; bladder cancer; cancer chemotherapy; controlled study; drug delivery system; drug efficacy; drug release; drug targeting; human; human cell; magnetic field; particle size; pH; priority journal; reaction optimization; surface property; T24 cell line; target cell
Type
journal article