https://scholars.lib.ntu.edu.tw/handle/123456789/410335
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang Y.-P. | en_US |
dc.contributor.author | Liao Y.-T. | en_US |
dc.contributor.author | Liu C.-H. | en_US |
dc.contributor.author | Yu J. | en_US |
dc.contributor.author | Alamri H.R. | en_US |
dc.contributor.author | Alothman Z.A. | en_US |
dc.contributor.author | Hossain M.S.A. | en_US |
dc.contributor.author | Yamauchi Y. | en_US |
dc.contributor.author | Wu K.C.-W. | en_US |
dc.creator | Wu K.C.-W.;Yamauchi Y.;Hossain M.S.A.;Alothman Z.A.;Alamri H.R.;Liu C.-H.;Liao Y.-T.;Wang Y.-P.;Yu J. | - |
dc.date.accessioned | 2019-05-24T08:31:45Z | - |
dc.date.available | 2019-05-24T08:31:45Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 23739878 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/410335 | - |
dc.description.abstract | Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe 3 O 4 ) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe 3 O 4 /CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe 3 O 4 /CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe 3 O 4 /CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems. ? 2017 American Chemical Society. | - |
dc.language | English | - |
dc.relation.ispartof | ACS Biomaterials Science and Engineering | en_US |
dc.subject | bladder cancer | - |
dc.subject | controlled release | - |
dc.subject | core-shell-corona nanoparticles | - |
dc.subject | magnetic guidance | - |
dc.subject | targeting | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Biocompatibility; Chemotherapy; Diseases; Iron research; Magnetism; Nanoparticles; Nanostructures; Particle size; Shells (structures); Synthesis (chemical); Bladder cancer cells; Bladder cancers; Controlled release; Core shell; Drug delivery system; Surface functionalities; Targeted chemotherapy; targeting; Nanomagnetics; alginic acid; arginylglycylaspartic acid; calcium phosphate; doxorubicin; superparamagnetic iron oxide nanoparticle; Article; biocompatibility; bladder cancer; cancer chemotherapy; controlled study; drug delivery system; drug efficacy; drug release; drug targeting; human; human cell; magnetic field; particle size; pH; priority journal; reaction optimization; surface property; T24 cell line; target cell | - |
dc.title | Trifunctional Fe 3 O 4 /CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/acsbiomaterials.7b00230 | - |
dc.identifier.scopus | 2-s2.0-85030856334 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030856334&doi=10.1021%2facsbiomaterials.7b00230&partnerID=40&md5=49a81c4a7b32b5f1360ca8be3623b2d3 | - |
dc.relation.pages | 2366-2374 | - |
dc.relation.journalvolume | 3 | - |
dc.relation.journalissue | 10 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Chemical Engineering | - |
crisitem.author.orcid | 0000-0002-0782-2328 | - |
crisitem.author.parentorg | College of Engineering | - |
顯示於: | 化學工程學系 |
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