https://scholars.lib.ntu.edu.tw/handle/123456789/410342
標題: | Gelatin methacrylate/carboxybetaine methacrylate hydrogels with tunable crosslinking for controlled drug release | 作者: | Lai T.C. Yu J. Tsai W.B. |
公開日期: | 2016 | 卷: | 4 | 期: | 13 | 起(迄)頁: | 2304-2313 | 來源出版物: | Journal of Materials Chemistry B | 摘要: | In this work, methacrylated gelatin (GelMA) based hydrogels were fabricated with carboxybetaine methacrylate (CBMA) to manipulate the properties of the gelatin-based hydrogels, since CBMA is a much smaller compound compared to gelatin. With the incorporation of CBMA, these hydrogels demonstrated better mechanical properties, a slower degradation rate, and a controlled drug release rate compared with the GelMA alone group. GelMA/CBMA hydrogels also showed good cell viability. As in the in vivo test, vascular endothelial growth factor (VEGF)-loaded GelMA/CBMA hydrogels displayed certain degrees of angiogenesis. These results indicate that GelMA/CBMA hydrogels are biocompatible, and the properties of GelMA/CBMA hydrogels can be easily tuned with the ratio of CBMA. These characteristics make the GelMA/CBMA hydrogel a promising material for drug delivery and tissue engineering. ? The Royal Society of Chemistry 2016. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/410342 | ISSN: | 20507518 | DOI: | 10.1039/c5tb02518d |
顯示於: | 化學工程學系 |
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