https://scholars.lib.ntu.edu.tw/handle/123456789/410733
Title: | Fabrication of Chlorophyll-Incorporated Nanogels for Potential Applications in Photothermal Cancer Therapy | Authors: | Chang R. Hsu C.-F. Tsai W.-B. |
Issue Date: | 2018 | Journal Volume: | 3 | Journal Issue: | 11 | Start page/Pages: | 16057-16062 | Source: | ACS Omega | Abstract: | Nanogels have been widely used in biomedical applications, such as carriers for hyperthermia cancer treatment, drug delivery, and imaging. Owing to the enhanced permeability and retention effect, nanogels have shown a great potential in cancer therapy. In this study, sodium copper chlorophyllin (SCC), a low cytotoxicity and biodegradable photothermal agent, was copolymerized with a nanogel of N-[3-(dimethylamino)propyl]methacrylamide. The nanogels could produce heat under exposure to a green laser with a 532 nm wavelength. The positively charged nature of the nanogels enhanced the endocytosis of the nanogels. The cell mortality was greatly enhanced with the treatment of the SCC-containing nanogels and green light illumination. Our results suggest the potential of SCC-containing nanogels in photothermal cancer therapy. ? 2018 American Chemical Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/410733 | ISSN: | 24701343 | DOI: | 10.1021/acsomega.8b01689 |
Appears in Collections: | 化學工程學系 |
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