|Title:||Fabrication of photothermo-responsive drug-loaded nanogel for synergetic cancer therapy||Authors:||Chang R.
|Keywords:||Anti-cancer;Drug delivery;N-isopropylacrylamide;Nanogel;Photothermo-responsive;Sodium copper chlorophyllin||Issue Date:||2018||Journal Volume:||10||Journal Issue:||10||Source:||Polymers||Abstract:||
Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment. ? 2018 by the authors.
|Appears in Collections:||化學工程學系|
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