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  4. A lipophilic IR-780 dye-encapsulated zwitterionic polymer-lipid micellar nanoparticle for enhanced photothermal therapy and NIR-based fluorescence imaging in a cervical tumor mouse model
 
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A lipophilic IR-780 dye-encapsulated zwitterionic polymer-lipid micellar nanoparticle for enhanced photothermal therapy and NIR-based fluorescence imaging in a cervical tumor mouse model

Journal
International Journal of Molecular Sciences
Journal Volume
19
Journal Issue
4
Date Issued
2018
Author(s)
Rajendrakumar S.K.
Chang N.-C.
Mohapatra A.
Uthaman S.
Lee B.-I.
Tsai W.-B.  
Park I.-K.
DOI
10.3390/ijms19041189
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/410735
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045446266&doi=10.3390%2fijms19041189&partnerID=40&md5=c9d529aee102c4d2450a8d0283a68fdf
Abstract
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in the bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders the interaction between the nanoparticles and the tumor cells and therefore limits the applications of PEGylated nanoparticles for therapeutic drug delivery. To overcome this limitation, zwitterionic materials can be used to enhance the systemic blood circulation and tumor-specific delivery of hydrophobic agents such as IR-780 iodide dye for photothermal therapy. Herein, we developed micellar nanoparticles using the amphiphilic homopolymer poly(12-(methacryloyloxy)dodecyl phosphorylcholine) (PCB-lipid) synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The PCB-lipid can self-assemble into micelles and encapsulate IR-780 dye (PCB-lipid-IR-780). Our results demonstrated that PCB-lipid-IR-780 nanoparticle (NP) exhibited low cytotoxicity and remarkable photothermal cytotoxicity to cervical cancer cells (TC-1) upon near-infrared (NIR) laser irradiation. The biodistribution of PCB-lipid-IR-780 showed higher accumulation of PCB-lipid-IR-780 than that of free IR-780 in the TC-1 tumor. Furthermore, following NIR laser irradiation of the tumor region, the PCB-lipid-IR-780 accumulated in the tumor facilitated enhanced tumor ablation and subsequent tumor regression in the TC-1 xenograft model. Hence, these zwitterionic polymer-lipid hybrid micellar nanoparticles show great potential for cancer theranostics and might be beneficial for clinical applications. ? 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Subjects
Cervical cancer
Hydrophobic
Imaging
IR-780
Micelle
Near-infrared
Photothermal therapy
Zwitterion
SDGs

[SDGs]SDG3

Other Subjects
dye; ir 780; nanoparticle; poly(12 (methacryloyloxy)dodecyl phosphorylcholine); polymer; unclassified drug; 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium; indole derivative; nanoparticle; polymer; animal cell; animal experiment; animal tissue; Article; cell viability; cervical cancer cell line; concentration (parameters); confocal microscopy; controlled study; cytotoxicity; experimental neoplasm; female; fluorescence imaging; fluorescence microscopy; irradiation; lipophilicity; micelle; mouse; MTS assay; nonhuman; particle size; photon correlation spectroscopy; photothermal therapy; polymerization; proton nuclear magnetic resonance; synthesis; temperature; tumor ablation; tumor volume; uterine cervix cancer; animal; chemistry; diagnostic imaging; drug screening; human; metabolism; phototherapy; procedures; synthesis; thermotherapy; tissue distribution; treatment outcome; tumor cell line; uterine cervix tumor; Animals; Cell Line, Tumor; Female; Humans; Hyperthermia, Induced; Indoles; Mice; Micelles; Nanoparticles; Phototherapy; Polymers; Tissue Distribution; Treatment Outcome; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays
Type
journal article

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