Nanoceramics on osteoblast proliferation and differentiation in bone tissue engineering
Journal
International Journal of Biological Macromolecules
Journal Volume
98
Pages
67-74
Date Issued
2017
Author(s)
Sai Nievethitha S.
Subhapradha N.
Saravanan D.
Selvamurugan N.
Srinivasan N.
Murugesan R.
Moorthi A.
Abstract
Bone, a highly dynamic connective tissue, consist of a bioorganic phase comprising osteogenic cells and proteins which lies over an inorganic phase predominantly made of CaPO 4 (biological apatite). Injury to bone can be due to mechanical, metabolic or inflammatory agents also owing pathological conditions like fractures, osteomyelitis, osteolysis or cysts may arise in enameloid, chondroid, cementum, or chondroid bone which forms the intermediate tissues of the body. Bone tissue engineering (BTE) applies bioactive scaffolds, host cells and osteogenic signals for restoring damaged or diseased tissues. Various bioceramics used in BTE can be bioactive (like glass ceramics and hydroxyapatite bioactive glass), bioresorbable (like tricalcium phosphates) or bioinert (like zirconia and alumina). Limiting the size of these materials to nano-scale has resulted in a higher surface area to volume ratio thereby improving multi-functionality, solubility, surface catalytic activity, high heat and electrical conductivity. Nanoceramics have been found to induce osteoconduction, osteointegration, osteogenesis and osteoinduction. The present review aims at summarizing the interactions of nanoceramics and osteoblast/stem cells for promoting the proliferation and differentiation of the osteoblast cells by nanoceramics as superior bone substitutes in bone tissue engineering applications. ? 2017 Elsevier B.V.
Subjects
Bioactive ceramics
Bone tissue engineering
Nanoceramics
Osteoblast
SDGs
Other Subjects
alloy; amoxicillin; angiopoietin 2; apatite; calcium chloride; ciprofloxacin; collagen type 1; doxorubicin; fucoidin; hydroxyapatite; integrin; macrogol 400; osteocalcin; titanium; zirconium oxide; nanomaterial; biocompatibility; biodegradation; bone development; bone regeneration; bone remodeling; bone tissue; cell differentiation; cell proliferation; electric conductivity; extracellular matrix; fracture healing; human; hydrophilicity; in vitro study; isoelectric point; nanoceramics; nanofabrication; nanotechnology; osteoblast; porosity; protein expression; Review; thermal conductivity; thermodynamics; tissue engineering; animal; bone; cell differentiation; cell proliferation; ceramics; chemistry; cytology; drug effects; osteoblast; pharmacology; procedures; tissue engineering; Animals; Bone and Bones; Cell Differentiation; Cell Proliferation; Ceramics; Humans; Nanostructures; Osteoblasts; Tissue Engineering
Type
review